MLB Prediction: Chicago White Sox vs New York Yankees (Tuesday, September 23 at 07:05 PM ET)
Introduction
| Market / Trend | CWS | NYY |
|---|---|---|
| Moneyline | +195 | -250 |
| Total (O/U) | 9.0 | |
| Run Line | +1.5 (100) | -1.5 (-120) |
| Last 5 RPG | 3.4 | 6.4 |
| Record | 58–98 | 88–68 |
| Lines: BetMGM, BetOnline.ag, BetRivers, BetUS +7 more | ||
More MLB picks: Chicago White Sox · New York Yankees
The Yankees enter this matchup analysis with momentum, winning 7 of their last 10 while averaging 5.5 runs per game, compared to a White Sox squad stuck at 2.6 RPG across the same span. The difference in offensive consistency and recent scoring output makes this MLB prediction straightforward: New York holds every statistical edge. With the Yankees’ lineup producing at a high clip and the White Sox struggling to generate runs on the road, the betting angle points toward a decisive edge for the home side and a strong case for the total to push past the number.
Game Time
Coverage starts at Tuesday, September 23 at 07:05 PM ET at Yankee Stadium, the short porch in right boosts pull-side power.
Odds & Spread Line
- Chicago White Sox: +195
- New York Yankees: -250
Total: 9
- Run Line — Chicago White Sox: +1.5 (+100)
- Run Line — New York Yankees: -1.5 (-120)
Latest Team Records
Chicago White Sox: 58-98 (Win %: 0.372)
New York Yankees: 88-68 (Win %: 0.564)
Injury Report
Both teams are currently healthy with no major injury concerns.
Key Player Stats
Chicago White Sox
- Lenyn Sosa: 0.259 AVG, 21 HR, 71 RBI
- Andrew Benintendi: 0.24 AVG, 20 HR, 63 RBI
- Miguel Vargas: 0.23 AVG, 15 HR, 57 RBI
New York Yankees
- Aaron Judge: 0.326 AVG, 49 HR, 105 RBI
- Cody Bellinger: 0.271 AVG, 29 HR, 97 RBI
- Jazz Chisholm Jr.: 0.242 AVG, 31 HR, 79 RBI
Team Analysis
Chicago White Sox
The White Sox enter this contest with a 1-4 mark in their last 5 games, averaging only 3.4 runs per outing, while their 2-8 record across the last 10 shows deeper struggles at just 2.6 RPG. That lack of consistency puts pressure on hitters like Lenyn Sosa to spark a lineup that has failed to sustain rallies. On the road, with a 25-50 record, the White Sox have repeatedly failed to translate individual power flashes into collective scoring threats.
Andrew Benintendi has shown some pop across the season, but his production hasn’t been enough to lift the club’s stagnant road offense. Miguel Vargas provides complementary power but remains part of a lineup that has rarely strung together high-scoring games in recent weeks. Against a surging Yankees squad at home, Chicago’s offensive rhythm and lack of depth leave them exposed to falling behind early and struggling to keep up on the scoreboard.
- Batting Average: 0.232
- Total Runs Scored: 618
- Home Runs: 156
- OBP: 0.302
- SLG: 0.372
- OPS: 0.674
- ERA: 4.23
- WHIP: 1.36
Away Record: 25-50 • Home Record: 33-48
Last 5 Games: 1-4 (3.4 RPG)
Last 10 Games: 2-8 (2.6 RPG)
New York Yankees
The Yankees look dominant entering this contest, with a 4-1 record in their last 5 games while averaging 6.4 RPG. That scoring surge has been fueled by Aaron Judge, who continues to anchor the middle of the order and generate consistent damage. The home mark of 44-31 underlines their confidence at Yankee Stadium, where their offense thrives with the help of the short porch in right.
Cody Bellinger’s balanced production and Jazz Chisholm Jr.’s power-speed profile have added depth behind Judge, giving New York three legitimate run producers. Their 7-3 record in the last 10 games, paired with a 5.5 RPG average, shows sustained offensive pressure that the White Sox have been unable to match. With both lineup depth and situational form pointing in their favor, the Yankees enter this matchup as the clear side to back.
- Batting Average: 0.25
- Total Runs Scored: 816
- Home Runs: 263
- OBP: 0.33
- SLG: 0.454
- OPS: 0.784
- ERA: 3.97
- WHIP: 1.26
Away Record: 44-37 • Home Record: 44-31
Last 5 Games: 4-1 (6.4 RPG)
Last 10 Games: 7-3 (5.5 RPG)
Head-to-Head History
New York Yankees lead 3–1 (Last 4 games)
- August 31, 2025: NYY 2 @ CHW 3
- August 30, 2025: NYY 5 @ CHW 3
- August 29, 2025: NYY 10 @ CHW 2
- August 28, 2025: NYY 10 @ CHW 4
Over/Under Trends
Chicago White Sox’s last 10 games have averaged 6.5 total runs, with 2 games that would have cleared today’s total of 9.
New York Yankees’ last 10 games have averaged 9.2 combined runs, with 3 games clearing the same number of 9.
Moneyline Betting Prediction
The Yankees’ recent 7-3 form, combined with their 44-31 home record and dominance in the last three head-to-head meetings, cements them as the superior side. With Aaron Judge leading a lineup that is consistently producing and supported by Cody Bellinger and Jazz Chisholm Jr., the White Sox’s lack of road scoring makes this a clear edge for New York.
We’re backing the New York Yankees — the read is consistent across metrics.
Over/Under Prediction
In their last five, the New York Yankees have produced 6.4 RPG and the Chicago White Sox 3.4. That output frames how this total sets up.
These teams are combining for 9.8 runs per game recently — above the posted total of 9.0. That points toward the Over 9.0.
Bookmakers
You’ll find these markets at: FanDuel, BetOnline.ag, LowVig.ag, Caesars, MyBookie.ag, DraftKings, Bovada, BetMGM, BetUS, Fanatics, BetRivers.
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MLB Predictions FAQ
How often are picks updated?
Daily. We update for confirmed lineups, injuries, and market moves. Check back near first pitch for final notes.
What’s a good price range for today’s pick (Sep 23, 2025)?
We list a target price in the post. If the market moves past that number, reduce stake size or pass instead of chasing worse odds.
