Prediction Details

MLB Prediction: San Diego Padres vs St. Louis Cardinals (Sunday, July 27 at 02:15 PM ET)

Introduction

This MLB prediction serves as a betting preview for the matchup between the San Diego Padres and St. Louis Cardinals. Both teams are eager to claim the victory with the Padres keen to improve their road game and the Cardinals, who have seen success at home, striving to maintain their strong record on home turf.

Game Time

Dust off those baseball gloves and grab your bats! Sunday, July 27 at 02:15 PM ET, the match is on. Expect some exciting plays and nail-biting moments taking place inside Busch Stadium where scoring trends lean under.

Moneyline Odds

San Diego Padres: +108
St. Louis Cardinals: -139
Over/Under Line: 9.0

Latest Team Records

San Diego Padres: 56-49 (Win %: 0.533)
St. Louis Cardinals: 54-52 (Win %: 0.509)

Injury Report

San Diego Padres: No major injuries reported.
St. Louis Cardinals: No major injuries reported.

Key Player Stats

San Diego Padres

  • Manny Machado: 0.294 AVG, 19 HR, 63 RBI
  • Fernando Tatis Jr.: 0.266 AVG, 17 HR, 44 RBI
  • Gavin Sheets: 0.25 AVG, 14 HR, 52 RBI

St. Louis Cardinals

  • Willson Contreras: 0.264 AVG, 14 HR, 61 RBI
  • Ivan Herrera: 0.312 AVG, 9 HR, 39 RBI
  • Alec Burleson: 0.285 AVG, 12 HR, 44 RBI

Team Analysis

San Diego Padres

The San Diego Padres may have had a mixed run of late, especially with their rocky away performance, but they shouldn’t be underestimated. Their powerful hitters, especially Manny Machado and Fernando Tatis Jr., are sure to bring their A-game, capitalizing on any possible gaps in the Cardinals’ defense. Despite the recent slip in form, the Padres have shown resilience and the potential to bounce back, especially when put under pressure.

While their recent performance is divided, what’s undeniable is their capability to score when it matters, a testament to their strong offensive lineup. With a blend of consistency and occasional flair, they have shown glimpses of brilliance on the road, something they will look to emphasise in their upcoming matchup.

  • Batting Average: 0.247
  • Total Runs Scored: 417
  • Home Runs: 88
  • OPS: 0.69
  • ERA: 3.6
  • WHIP: 1.23

Away Record: 25-31 • Home Record: 31-18
Last 5 Games: 1-4 (3.0 RPG)
Last 10 Games: 4-6 (3.5 RPG)


St. Louis Cardinals

The Cardinals’ home advantage cannot be overstated and has been instrumental in maintaining their strong form. The likes of Willson Contreras and Ivan Herrera have been swinging some hot bats lately making a significant impact at the plate. Regardless of the Padres’ attempt to turn the tide on the road, the Cardinals have shown they can stand their ground at home.

The squad’s recent form is somewhat mediocre, but the Cardinals been looking good during their home games. Moreover, they have a history of pulling out wins just when they’re needed — a trend that looks set to continue this Sunday. The Cardinals’ ability to defend their turf will play a vital role in this matchup.

  • Batting Average: 0.252
  • Total Runs Scored: 474
  • Home Runs: 103
  • OPS: 0.713
  • ERA: 4.17
  • WHIP: 1.29

Away Record: 23-31 • Home Record: 31-21
Last 5 Games: 2-3 (3.4 RPG)
Last 10 Games: 4-6 (3.5 RPG)


Head-to-Head History

St. Louis Cardinals lead 2–1 (Last 3 games)

  • 2025-07-26: SD 3 @ STL 1
  • 2025-07-25: SD 0 @ STL 3
  • 2025-07-24: SD 7 @ STL 9

Over/Under Trends

San Diego Padres’ last 10 games have averaged 6.5 total runs per game, with 1 of those going over the posted total of 9.0.

St. Louis Cardinals’ last 10 games have seen an average of 8.7 combined runs, with 4 games clearing the same line of 9.0.

Moneyline Betting Prediction

Despite the mixed form, the San Diego Padres are a team capable of surprises. Considering the strength of their lineup, they have every chance to turn the tide on road. With their strong offense, we are backing them to come out swinging and pull off an upset in a tough matchup.

We’re backing the San Diego Padres as a value play with upside.

Over/Under Prediction

In their last five games, the St. Louis Cardinals have posted 3.4 runs per game, while the San Diego Padres have averaged 3.0. This recent output is key to judging the total.

These teams are combining for 6.4 runs per game recently — below the posted total of 9.0, a crucial benchmark in MLB betting markets. Our pick is Under 9.0.

Bookmakers

You’ll find these markets at: BetOnline.ag, Fanatics, LowVig.ag, Bovada, FanDuel, Caesars, MyBookie.ag, BetMGM, DraftKings, BetUS, BetRivers. Parlamaz may earn affiliate commissions from links in this article.