Introduction

Get ready for a compelling MLB clash as the San Diego Padres visit the St. Louis Cardinals in a cross-league showdown. Both teams bring intriguing form, high-level talent, and a sense of urgency as they jockey for playoff position.

Game Time

Matchup set for Friday, July 25 at 07:15 PM ET at pitcher-friendly Busch Stadium in St. Louis.

Moneyline Odds

San Diego Padres: -127
St. Louis Cardinals: +116
Over/Under Line: 8.5

Latest Team Records

San Diego Padres have a record of 55-47 with a win percentage of 0.539, while the St. Louis Cardinals hold a record of 52-51 with a win percentage of 0.505.

Injury Report

Both teams are currently healthy with no major injury concerns.

Key Player Stats

San Diego Padres

• Manny Machado: 0.285 AVG, 18 HR, 61 RBI
• Fernando Tatis Jr.: 0.262 AVG, 16 HR, 42 RBI
• Gavin Sheets: 0.254 AVG, 14 HR, 51 RBI

St. Louis Cardinals

• Alec Burleson: 0.29 AVG, 12 HR, 44 RBI
• Ivan Herrera: 0.305 AVG, 8 HR, 37 RBI
• Willson Contreras: 0.258 AVG, 13 HR, 57 RBI

Team Analysis

San Diego Padres

The San Diego Padres have displayed a persistent performance away from home this season. The formidable duo, Manny Machado and Fernando Tatis Jr., have been instrumental in their recent games providing both strength and depth to their squad. The Padres, currently standing with a subtly impressive away record, strive to improve their form further.

Even though they have been inconsistent in their last five games, with a 2-3 record, the Padres’ ability to rebound could come into play during this matchup. Their three games’ winning streak against different teams highlights their adaptability, while their close-knit, cohesive team play demonstrates the danger they pose for their opponents.

• Batting Average: 0.245
• Total Runs Scored: 407
• Home Runs: 86
• OPS: 0.688
• ERA: 3.58
• WHIP: 1.23

Away Record: 24-29 • Home Record: 31-18
Last 5 Games: 2-3 (3.4 RPG)
Last 10 Games: 6-4 (3.8 RPG)

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St. Louis Cardinals

The St. Louis Cardinals have had a mixed run at home this season. The trio of Burleson, Herrera, and Contreras has contributed significantly to their success. Despite a 1–4 slump in their last five games, they remain a threat at Busch Stadium and have the tools to rebound if their key hitters step up.

Lacking a consistent winning streak recently, the Cardinals will be relying on their home-ground advantage as well as their key players’ form to secure a win. Keep an eye out for Ivan Herrera, who has been showing noteworthy offensive swings and skill.

• Batting Average: 0.252
• Total Runs Scored: 461
• Home Runs: 100
• OPS: 0.714
• ERA: 4.21
• WHIP: 1.29

Away Record: 23-31 • Home Record: 29-20
Last 5 Games: 1-4 (2.8 RPG)
Last 10 Games: 3-7 (4.1 RPG)

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Head-to-Head History

No recent matchups between these teams in 2025.

Over/Under Trends

San Diego Padres’ last 10 games have averaged 6.4 total runs per game, with 3 of those going over the posted total of 8.5.

St. Louis Cardinals’ last 10 games have seen an average of 9.7 combined runs, with 7 games clearing the same line of 8.5.

Moneyline Betting Prediction

Taking into account the recent form of both teams, the St. Louis Cardinals seem to hold the edge. With the home advantage and the potential of Alec Burleson and Ivan Herrera, the Cardinals have the upper hand. Though the Padres have put up a spirited performance and hold potential, the Cardinals’ home form suggests they are the team that might emerge victorious in this matchup.

With home momentum and key contributors, this looks like a smart spot for the St. Louis Cardinals to deliver as underdogs.

Over/Under Prediction

In their last five games, the St. Louis Cardinals have posted 2.8 runs per game, while the San Diego Padres have averaged 3.4. This recent output is key to judging the total.

These teams are combining for 6.2 runs per game recently — below the posted total of 8.5, a crucial pivot point in betting markets. Our pick is Under 8.5.

Bookmakers

Betting lines provided by: FanDuel, LowVig.ag, BetOnline.ag, Caesars, DraftKings, MyBookie.ag, BetMGM, Bovada, BetRivers, Fanatics, BetUS.

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