Prediction Details

MLB Prediction: San Diego Padres vs Miami Marlins (Monday, July 21 at 06:40 PM ET)

Introduction

This American League and National League showdown is set to heat up as the San Diego Padres take on the Miami Marlins. These two squads are set to clash in a game that promises to be a blend of tactics and firepower. As the Padres aim to maintain their momentum and the Marlins look to turn the tide, it’s anybody’s game.

Game Time

Catch this baseball slugfest on Monday, July 21 at 06:40 PM ET. Both teams will be looking to make their mark on loanDepot Park, a venue known for its affinity with pitchers.

Moneyline Odds

San Diego Padres: +110
Miami Marlins: -130
Over/Under Line: 8.0

Latest Team Records

The San Diego Padres are charging with a solid record of 53 wins and 45 losses, currently sporting a winning percentage of 0.541. Meanwhile, the Miami Marlins sit with a record of 46 wins and 51 losses, translating into a winning percentage of 0.474.

Injury Report

Heading into this matchup, both teams are fit and firing, making this a full-strength battle that fans can’t afford to miss.

Key Player Stats

San Diego Padres

  • Manny Machado: 0.287 AVG, 18 HR, 60 RBI
  • Fernando Tatis Jr.: 0.266 AVG, 16 HR, 42 RBI
  • Gavin Sheets: 0.259 AVG, 14 HR, 50 RBI

Miami Marlins

  • Kyle Stowers: 0.299 AVG, 21 HR, 59 RBI
  • Otto Lopez: 0.249 AVG, 11 HR, 52 RBI
  • Agustin Ramirez: 0.241 AVG, 14 HR, 42 RBI

Team Analysis

San Diego Padres

The Padres continue to build their identity around a solid offensive core. Manny Machado and Fernando Tatis Jr. headline a lineup with big potential, while Gavin Sheets has become a dependable presence in key spots.

They’ve demonstrated strong performances at home and will look to lean on that familiarity in this matchup. If their starting pitching holds up, the Padres’ offense has more than enough firepower to tip this contest in their favor.

  • Batting Average: 0.246
  • Total Runs Scored: 392
  • Home Runs: 84
  • OPS: 0.69
  • ERA: 3.63
  • WHIP: 1.23

Away Record: 23-27 • Home Record: 31-18


Miami Marlins

The Marlins are riding a wave of confidence with standout offensive contributions from Kyle Stowers, Otto Lopez, and Agustin Ramirez. This trio has helped turn Miami into a much more dangerous lineup than earlier in the season.

Although their home performance has been shaky, their roster is healthy and energized. If the Marlins can capitalize on scoring opportunities early, they could apply real pressure on the Padres’ bullpen.

  • Batting Average: 0.254
  • Total Runs Scored: 419
  • Home Runs: 90
  • OPS: 0.709
  • ERA: 4.55
  • WHIP: 1.32

Away Record: 24-24 • Home Record: 22-28


Head-to-Head History

Miami Marlins 1–2 San Diego Padres (Last 3 games)

  • 2025-05-28: MIA 10 @ SD 8
  • 2025-05-28: MIA 6 @ SD 8
  • 2025-05-27: MIA 3 @ SD 4

Moneyline Betting Prediction

With their recent form, robust lineup, and ability to turn the tide when it matters the most, betting on the San Diego Padres to pull off a win seems to be a value proposition. Their offensive strength backed by their key players is an asset that can thrust them into victory. We confidently back the Padres in this matchup.

Bank on the San Diego Padres at +110 to come up victorious.

Bookmakers

Your one-stop-shop for the best odds and betting options are: BetOnline.ag, LowVig.ag, Bovada, Caesars, BetUS, DraftKings, MyBookie.ag, FanDuel, BetMGM, BetRivers, Fanatics.

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