Introduction

Get ready for an American League and National League showdown as the Houston Astros take on the Miami Marlins. With the Astros looking to establish dominance on the road, and the Marlins aiming to fortify their home turf, this MLB prediction promises an intriguing matchup.

Game Time

First pitch will be thrown on Wednesday, August 6 at 04:40 PM ET inside pitcher-friendly loanDepot Park, a consistent under venue.

Odds & Spread Line

Houston Astros: -120
Miami Marlins: -105
Over/Under Line: 8.5
Spread Line:
Houston Astros: -1.5 (+155)
Miami Marlins: +1.5 (-177)

Latest Team Records

Houston Astros: 64-50 (Win %: 0.561)
Miami Marlins: 55-57 (Win %: 0.491)

Injury Report

Houston Astros are missing Isaac Paredes (Hamstring), listed as 10-Day-IL; Lance McCullers Jr. (Finger), listed as 15-Day-IL; Brandon Walter (Elbow), listed as 15-Day-IL. No other significant injuries are reported.

The Miami Marlins are currently healthy with no major injury concerns.

Key Player Stats

Houston Astros

• Jeremy Pena: 0.324 AVG, 11 HR, 41 RBI
• Jose Altuve: 0.279 AVG, 18 HR, 57 RBI
• Isaac Paredes: 0.259 AVG, 19 HR, 50 RBI

Miami Marlins

• Kyle Stowers: 0.295 AVG, 25 HR, 71 RBI
• Agustin Ramirez: 0.242 AVG, 17 HR, 50 RBI
• Otto Lopez: 0.247 AVG, 11 HR, 55 RBI

Team Analysis

Houston Astros

The Houston Astros come into this game with a decent road record, but their recent form has been inconsistent. They’ve won just two of their last five games, averaging four runs per game. While their bats have had flashes of brilliance, they have struggled to find consistency. Jose Altuve and Jeremy Pena have been the key contributors for the team, but the absence of Isaac Paredes due to injury might hurt their offense.

On the positive side, the Astros have a good record against the Marlins, winning their last two encounters. This head-to-head history might give them an edge in this game, and they’ll be hoping to continue their dominance over the Marlins. However, they’ll need to step up their game and find consistency to secure a win on the road.

• Batting Average: 0.257
• Total Runs Scored: 486
• Home Runs: 123
• OPS: 0.725
• ERA: 3.7
• WHIP: 1.19

Away Record: 29-26 • Home Record: 35-24
Last 5 Games: 2-3 (4.0 RPG)
Last 10 Games: 4-6 (3.9 RPG)

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Miami Marlins

The Miami Marlins have been solid at home, but their overall record is below .500. They’ve won three of their last five games, showing some offensive potential with an average of 5.4 runs per game in this stretch. The Marlins have been leaning heavily on the hitting prowess of Kyle Stowers, who has been their most consistent offensive threat.

Playing at home, the Marlins will be looking to leverage their advantageous position to overcome the Astros. However, they’ll need to overcome their recent history against the Astros, having lost their last two encounters. If the Marlins can keep their bats hot and capitalize on their home advantage, they might just turn the tide in this matchup.

• Batting Average: 0.252
• Total Runs Scored: 477
• Home Runs: 107
• OPS: 0.712
• ERA: 4.41
• WHIP: 1.3

Away Record: 28-26 • Home Record: 27-31
Last 5 Games: 3-2 (5.4 RPG)
Last 10 Games: 6-4 (4.4 RPG)

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Head-to-Head History

Houston Astros lead 2–0 (Last 2 games)

• August 05, 2025: HOU 7 @ MIA 3
• August 04, 2025: HOU 8 @ MIA 2

Over/Under Trends

Houston Astros’ last 10 games have averaged 7.8 total runs per game, with 5 of those going over the posted total of 8.5.

Miami Marlins’ last 10 games have seen an average of 8.8 combined runs, with 5 games clearing the same line of 8.5.

Moneyline Betting Prediction

Given the Astros’ recent form and their head-to-head dominance over the Marlins, backing the Houston Astros appears to be the smart move here. Despite their road record, the Astros have been performing well against the Marlins and will be looking to continue their good form.

Backing the Houston Astros feels like the smart move here.

Over/Under Prediction

Averaging 5.4 runs per game lately, the Miami Marlins are ramping up offensively, while the Houston Astros are putting up 4.0. That could influence how this matchup shapes up against the total.

These teams are combining for 9.4 runs per game recently — above the posted total of 8.5, a crucial pivot point in betting markets. Our pick is Over 8.5.

Bookmakers

Lines retrieved from: BetOnline.ag, LowVig.ag, FanDuel, MyBookie.ag, Caesars, DraftKings, Bovada, Fanatics, BetUS, BetMGM, BetRivers.

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