Introduction

A clash between the beloved Houston Astros and Arizona Diamondbacks promises to be a fierce American League and National League showdown. With both teams boasting compelling rosters and impressive records, this intra-league battle is shaping up to be a thrilling contest filled with tension, high-stakes, and electrifying plays.

Game Time

First pitch will be thrown at Wednesday, July 23 at 03:40 PM ET under the retractable roof at Chase Field, a neutral-hitting park.

Moneyline Odds

Houston Astros: -102
Arizona Diamondbacks: -115
Over/Under Line: 8.5

Latest Team Records

Houston Astros have a record of 58-42 with a win percentage of 0.58, while the Arizona Diamondbacks hold a record of 50-51 with a win percentage of 0.495.

Injury Report

Key injuries for the Houston Astros include:

• Spencer Arrighetti (Thumb) – Status: 60-Day-IL. Arrighetti (thumb) tossed three scoreless innings in a rehab start with Double-A Corpus Christi on Saturday, allowing one hit and no walks while striking out four batters.
• Jacob Melton (Ankle) – Status: 10-Day-IL. Melton (ankle) recently transitioned his rehab program to the Astros’ spring training facility in Florida and is in the midst of hitting, running and throwing progressions, MLB.com reports.
• Jake Meyers (Calf) – Status: 10-Day-IL. Astros general manager Dana Brown said Sunday that he expects Meyers (calf) to be out for “at the very minimum, three-plus weeks,” Chandler Rome of The Athletic reports.
• Shawn Dubin (Forearm) – Status: 15-Day-IL. Dubin (forearm) has resumed throwing from flat ground in Florida, MLB.com reports.

The Arizona Diamondbacks are currently healthy with no major injury concerns.

Key Player Stats

Houston Astros

• Jeremy Pena: 0.322 AVG, 11 HR, 40 RBI
• Jose Altuve: 0.278 AVG, 17 HR, 53 RBI
• Isaac Paredes: 0.259 AVG, 19 HR, 50 RBI

Arizona Diamondbacks

• Eugenio Suarez: 0.257 AVG, 36 HR, 86 RBI
• Josh Naylor: 0.293 AVG, 11 HR, 58 RBI
• Geraldo Perdomo: 0.27 AVG, 10 HR, 72 RBI

Team Analysis

Houston Astros

Despite battling through injuries, the Houston Astros continue to field a competitive and resilient lineup. Anchored by veteran leaders like Jeremy Peña, Jose Altuve, and Isaac Paredes, their offense remains capable of generating runs in key moments. Their ability to stay in contention under adversity speaks volumes about their depth and experience.

With a strong home record and a reliable pitching staff, the Astros are well-positioned to maintain pressure throughout this matchup. Their disciplined approach at the plate and consistency in closing out games keep them firmly in the conversation as postseason contenders.

• Batting Average: 0.259
• Total Runs Scored: 442
• Home Runs: 114
• OPS: 0.733
• ERA: 3.62
• WHIP: 1.17

Away Record: 25-23 • Home Record: 33-19

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Arizona Diamondbacks

The Arizona Diamondbacks bring a well-rounded offensive attack into this matchup, highlighted by the efforts of Eugenio Suárez, Josh Naylor, and Geraldo Perdomo. Their lineup has proven capable of stringing together scoring opportunities and putting pressure on opposing pitchers across innings.

With a balanced split between their home and road records, the Diamondbacks remain a versatile threat. Their power-hitting ability and run production have been key strengths, and they’ll look to exploit any gaps left by Houston’s injury setbacks. If the bats stay hot, Arizona is more than equipped to keep this game competitive.

• Batting Average: 0.252
• Total Runs Scored: 518
• Home Runs: 146
• OPS: 0.776
• ERA: 4.6
• WHIP: 1.33

Away Record: 24-25 • Home Record: 26-26

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Head-to-Head History

Arizona Diamondbacks 0–1 Houston Astros (Last 1 games)

• 2025-07-22: HOU 6 @ ARI 3

Moneyline Betting Prediction

The Arizona Diamondbacks have displayed an upward curve in their recent performances. Their current form has seen them winning 4 out of their last five games and hitting well offensively. Sharp plays from Suarez, Naylor, and Perdomo have bolstered this progression and given them a decisive edge. Their confidence and offensive power should carry them with an advantage over the Astros, who have stumbled lately. So for a strategic punt, consider placing your faith in the Diamondbacks.

The Arizona Diamondbacks at -115 look like a strong bet to handle business.

Bookmakers

Betting lines provided by: FanDuel, Fanatics, MyBookie.ag.

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