Introduction

Don your jerseys and ready the nachos: an American League and National League showdown is brewing. The forceful Houston Astros are prepping to swing bat against the vibrant Arizona Diamondbacks in an anticipated MLB clash. Ready for some midsummer thunder? Let’s dig into the matchup and evaluate who may be walking away victorious.

Game Time

First pitch will be thrown at Tuesday, July 22 at 09:40 PM ET under the retractable roof at Chase Field, a neutral-hitting park.

Moneyline Odds

Houston Astros: -125
Arizona Diamondbacks: +105
Over/Under Line: 8.0

Latest Team Records

Houston Astros have a record of 57-42 with a win percentage of 0.576, while the Arizona Diamondbacks hold a record of 50-50 with a win percentage of 0.5.

Injury Report

Key injuries for the Houston Astros include:

• Spencer Arrighetti (Thumb) – Status: 60-Day-IL. Arrighetti (thumb) tossed three scoreless innings in a rehab start with Double-A Corpus Christi on Saturday, allowing one hit and no walks while striking out four batters.
• Jacob Melton (Ankle) – Status: 10-Day-IL. Melton (ankle) recently transitioned his rehab program to the Astros’ spring training facility in Florida and is in the midst of hitting, running and throwing progressions, MLB.com reports.

Key injuries for the Arizona Diamondbacks include:

• Jalen Beeks (Back) – Status: 15-Day-IL. Beeks (back) is slated to throw another bullpen session Tuesday, Alex Weiner of ArizonaSports.com reports.
• Shelby Miller (Forearm) – Status: 15-Day-IL. Miller (forearm) is scheduled to face live batters Tuesday, Alex Weiner of ArizonaSports.com reports.
• Gabriel Moreno (Finger) – Status: 60-Day-IL. Manager Torey Lovullo said Monday that Moreno’s (finger) CT scan showed he has not completely healed, and the catcher will likely need another couple weeks before resuming full baseball activities, Nick Piecoro of The Arizona Republic reports.

Key Player Stats

Houston Astros

• Jeremy Pena: 0.322 AVG, 11 HR, 40 RBI
• Jose Altuve: 0.278 AVG, 17 HR, 53 RBI
• Isaac Paredes: 0.259 AVG, 19 HR, 50 RBI

Arizona Diamondbacks

• Eugenio Suarez: 0.257 AVG, 35 HR, 85 RBI
• Josh Naylor: 0.292 AVG, 11 HR, 58 RBI
• Geraldo Perdomo: 0.272 AVG, 10 HR, 72 RBI

Team Analysis

Houston Astros

Despite having a relatively positive season, the Astros are facing a wall as of recent. Their 2-3 record in the last five games and pretty low scoring rate expose their recent difficulties in maintaining a consistent rhythm. Players like Jose Altuve and Jeremy Pena have shown sparks of brilliance, but their efforts haven’t been enough to fully prevent the downturn.

Inconsistency is the word that comes to mind when looking at the last 10 games. Although boasting a potent batting lineup with Isaac Paredes, the team is lagging behind in terms of delivering solid performances consistently. As they kick into the final stretch of the season, it’s high time for them to steady their ground and rebound.

• Batting Average: 0.258
• Total Runs Scored: 436
• Home Runs: 112
• OPS: 0.733
• ERA: 3.64
• WHIP: 1.17

Away Record: 24-23 • Home Record: 33-19
Last 5 Games: 2-3 (4.8 RPG)
Last 10 Games: 3-7 (4.5 RPG)

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Arizona Diamondbacks

The Arizona Diamondbacks are demonstrating a confident stride of late, maintaining a 4-1 momentum in their last five games. Key players like Eugenio Suarez and Josh Naylor are stepping up and delivering commendable performances, contributing significantly to the team’s recent scoring count and their upward trend.

Arizona’s relatively solid home and away records reflect their overall level-headedness. Players like Geraldo Perdomo have been trailing consistent output, which provides an optimistic outlook for their upcoming matches. If they can uphold this glowing form and take advantage of their current upswing, they could pose a formidable challenge to the Astros.

• Batting Average: 0.252
• Total Runs Scored: 515
• Home Runs: 145
• OPS: 0.776
• ERA: 4.58
• WHIP: 1.33

Away Record: 24-25 • Home Record: 26-25
Last 5 Games: 4-1 (6.4 RPG)
Last 10 Games: 6-4 (5.4 RPG)

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Head-to-Head History

No recent matchups between these teams in 2025.

Over/Under Trends

Houston Astros‘s recent games have seen an average of 5.7 total runs scored per game over their last 7 matchups, with 2 games going over the total line.

Arizona Diamondbacks‘s recent games have averaged 11.9 total runs per game over their last 7 matchups, with 5 games going over the total of 8.0.

Moneyline Betting Prediction

The Arizona Diamondbacks, with their climbing form, should be a smart pick. Players like Eugenio Suarez and Josh Naylor have been catalyzing the team’s scoring potential and boosting the team’s morale to stride confidently towards victory. The Diamondbacks’ recent confidence, backed by impressive key player form, argues for a positive outcome for them. Take the Arizona Diamondbacks for the win.

Our lean lands on the Arizona Diamondbacks at +105 to cover their edge.

Over/Under Prediction

Averaging 6.4 runs per game lately, the Arizona Diamondbacks are ramping up offensively, while the Houston Astros are putting up 4.8. That could influence how this matchup shapes up against the total.

These teams are combining for 11.2 runs per game recently — above the posted total of 8.0, a crucial pivot point in betting markets. Our pick is Over 8.0.

Bookmakers

Odds courtesy of: FanDuel, MyBookie.ag, BetOnline.ag, LowVig.ag, Caesars, DraftKings, Bovada, BetRivers, BetMGM.

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