Introduction

The Houston Astros are set to lock horns with the Arizona Diamondbacks in this much-anticipated American League and National League showdown. It’s going to be an intense mashup, as both look to secure their positions in the league. Baseball fans are bracing themselves for a game charged with talent and strategy, and bettors are already playing the odds.

Game Time

The game kicks off at Monday, July 21 at 09:40 PM ET under the retractable roof at Chase Field, a neutral-hitting park.

Moneyline Odds

Houston Astros: +130
Arizona Diamondbacks: -154
Over/Under Line: 9.0

Latest Team Records

Houston Astros have a record of 56-42 with a win percentage of 0.571, while the Arizona Diamondbacks hold a record of 49-50 with a win percentage of 0.495.

Injury Report

Key injuries for the Houston Astros include:

• Shawn Dubin (Forearm) – Status: 15-Day-IL. Dubin (forearm) has resumed throwing from flat ground in Florida, MLB.com reports.
• Zach Dezenzo (Hand) – Status: 60-Day-IL. Dezenzo (hand) has not resumed hitting since being placed on the injured list June 3, Matt Kawahara of the Houston Chronicle reports.

Key injuries for the Arizona Diamondbacks include:

• Gabriel Moreno (Finger) – Status: 60-Day-IL. Moreno (finger) was transferred to the 60-day injured list Friday.
• Ryan Thompson (Shoulder) – Status: 15-Day-IL. Thompson (shoulder) has begun a throwing program, Alex Weiner of Arizona Sports reports.
• Shelby Miller (Forearm) – Status: 15-Day-IL. Miller (forearm) began a throwing program Thursday, Alex Weiner of ArizonaSports.com reports.

Key Player Stats

Houston Astros

• Jeremy Pena: 0.322 AVG, 11 HR, 40 RBI
• Jose Altuve: 0.279 AVG, 17 HR, 53 RBI
• Isaac Paredes: 0.259 AVG, 19 HR, 50 RBI

Arizona Diamondbacks

• Eugenio Suarez: 0.254 AVG, 33 HR, 81 RBI
• Josh Naylor: 0.291 AVG, 11 HR, 58 RBI
• Geraldo Perdomo: 0.272 AVG, 10 HR, 71 RBI

Team Analysis

Houston Astros

The Houston Astros bring a formidable lineup into this matchup, with offensive rhythm driven by standouts Jeremy Pena, Jose Altuve, and Isaac Paredes. These players have consistently played pivotal roles, delivering timely hits and maintaining pressure on opposing pitchers. Their ability to control the tempo at the plate gives the Astros a strong foundation heading into this contest.

On the road, Houston has managed to remain stable, showcasing a balanced ability to compete in various ballparks. If Altuve and Paredes can spark run production early, the Astros will likely have the tools necessary to keep this matchup competitive from start to finish.

• Batting Average: 0.258
• Total Runs Scored: 425
• Home Runs: 110
• OPS: 0.73
• ERA: 3.64
• WHIP: 1.17

Away Record: 24-23 • Home Record: 33-19

Arizona Diamondbacks

The Arizona Diamondbacks enter this matchup with a potent offense built around Eugenio Suarez, Josh Naylor, and Geraldo Perdomo. This trio has anchored their scoring capabilities, offering both power and consistency at the plate. When this core is firing, the Diamondbacks can be difficult to contain over nine innings.

Arizona’s lineup is well-equipped to challenge opposing pitchers, especially when capitalizing on early opportunities. If Suarez and Naylor continue to produce runs, the Diamondbacks will be in position to control the flow of the game and keep pressure on the Astros throughout.

• Batting Average: 0.253
• Total Runs Scored: 510
• Home Runs: 143
• OPS: 0.776
• ERA: 4.6
• WHIP: 1.33

Away Record: 24-25 • Home Record: 26-25

Head-to-Head History

No recent matchups between these teams in 2025.

Moneyline Betting Prediction

With their offensive prowess and current upward momentum, the Arizona Diamondbacks are the wise choice. They’ve shown a significant improvement over the past few games and have a team well-equipped to maintain that trend. With key players in great form, betting on the Diamondbacks is a smart value play.

Our lean lands on the Arizona Diamondbacks at -154 to cover their edge.

Bookmakers

Odds courtesy of: BetOnline.ag, LowVig.ag, Caesars, DraftKings, MyBookie.ag, FanDuel, Bovada, BetUS, BetMGM, BetRivers, Fanatics.

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