Introduction

This AL showdown between the Orioles and Guardians brings two teams in very different form — one trying to claw back into contention, the other building serious momentum. Bettors should take notice of the recent trends here.

Game Time

The game kicks off at Tuesday, July 22 at 06:40 PM ET in Progressive Field, where weather can dictate scoring.

Moneyline Odds

Baltimore Orioles: +118
Cleveland Guardians: -130
Over/Under Line: 8.5

Latest Team Records

Baltimore Orioles have a record of 44-54 with a win percentage of 0.449, while the Cleveland Guardians hold a record of 48-50 with a win percentage of 0.49.

Injury Report

Key injuries for the Baltimore Orioles include:

• Zach Eflin (Back) – Status: 15-Day-IL. Eflin (back) struck out five and allowed five unearned runs on three hits and one walk over four innings in a rehab start Thursday in the rookie-level Florida Complex League.
• Adley Rutschman (Oblique) – Status: 10-Day-IL. Rutschman (oblique) is expected to start a minor-league rehab assignment with Triple-A Norfolk on Tuesday, Roch Kubatko of MASNSports.com reports.
• Chadwick Tromp (Back) – Status: 10-Day-IL. Tromp (back) will begin a rehab assignment at Single-A Delmarva on Friday, Roch Kubatko of MASNSports.com reports.

Key injuries for the Cleveland Guardians include:

• Lane Thomas (Foot) – Status: 10-Day-IL. Thomas (foot) isn’t in the lineup for Saturday’s game against the Tigers.
• Will Brennan (Elbow) – Status: 60-Day-IL. The Guardians transferred Brennan (elbow) to the 60-day injured list Friday.

Key Player Stats

Baltimore Orioles

• Ryan O’Hearn: 0.282 AVG, 12 HR, 36 RBI
• Gunnar Henderson: 0.28 AVG, 11 HR, 34 RBI
• Ramon Laureano: 0.276 AVG, 11 HR, 36 RBI

Cleveland Guardians

• Jose Ramirez: 0.295 AVG, 19 HR, 52 RBI
• Steven Kwan: 0.285 AVG, 6 HR, 32 RBI
• Angel Martinez: 0.246 AVG, 9 HR, 37 RBI

Team Analysis

Baltimore Orioles

The Baltimore Orioles are navigating a tough stretch, but their offensive lineup still holds the potential to shift momentum. Players like Ryan O’Hearn, Gunnar Henderson, and Ramon Laureano have delivered steady contributions, and if that core can ignite, Baltimore could see a turnaround in their scoring production.

While their overall form has been uneven, the Orioles have shown flashes of promise, particularly on the road. With an away record that reflects their resilience outside of Camden Yards, Baltimore will look to capitalize on matchups and regain footing against a competitive Guardians squad.

• Batting Average: 0.239
• Total Runs Scored: 402
• Home Runs: 114
• OPS: 0.701
• ERA: 4.96
• WHIP: 1.41

Away Record: 22-29 • Home Record: 22-25

Cleveland Guardians

The Cleveland Guardians are hitting a confident stride, powered by consistent efforts from Jose Ramirez, Steven Kwan, and Angel Martinez. These three have become central to the Guardians’ offensive engine, bringing both power and precision to the plate.

Even though their home record sits just under .500, the Guardians have shown they can manufacture runs and stay composed in tight spots. If their core bats continue producing and the pitching holds steady, Cleveland is in a strong position to control the tempo in this matchup.

• Batting Average: 0.223
• Total Runs Scored: 371
• Home Runs: 102
• OPS: 0.665
• ERA: 3.96
• WHIP: 1.34

Away Record: 26-26 • Home Record: 22-24

Head-to-Head History

Cleveland Guardians 1–2 Baltimore Orioles (Last 3 games)

• 2025-04-17: CLE 2 @ BAL 6
• 2025-04-16: CLE 1 @ BAL 9
• 2025-04-15: CLE 6 @ BAL 3

Moneyline Betting Prediction

Recent form can be a strong indicator of future success, and the Cleveland Guardians have shown resilience and an impressive offensively inclined game lately. Balanced with their adequate home performance, it seems they are in a position to capitalize on the Orioles’ apparent away-venue struggle. For this reason, a bet on the Cleveland Guardians appears to be the more reasonable stake.

Our lean lands on the Cleveland Guardians at -130 to cover their edge.

Bookmakers

Odds courtesy of: FanDuel, MyBookie.ag, LowVig.ag, BetOnline.ag, Caesars, DraftKings, Bovada, BetRivers, BetMGM, Fanatics, BetUS.

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