Introduction

Get ready for an exciting MLB showdown between the Baltimore Orioles and the Cleveland Guardians. With the Orioles trying to build momentum and the Guardians striving to maintain their recent form, this American League matchup promises a great deal of intrigue and fiercely competitive baseball.

Game Time

Matchup set for Monday, July 21 at 06:40 PM ET in Progressive Field, where weather can dictate scoring.

Moneyline Odds

Baltimore Orioles: +115
Cleveland Guardians: -141
Over/Under Line: 8.0

Latest Team Records

Baltimore Orioles have a record of 43-54 with a win percentage of 0.443, while the Cleveland Guardians hold a record of 47-50 with a win percentage of 0.485.

Injury Report

Key injuries for the Baltimore Orioles include:

• Scott Blewett (Elbow) – Status: 15-Day-IL. The Orioles placed Blewett on the 15-day injured list Sunday due to right elbow discomfort.
• Ryan Mountcastle (Hamstring) – Status: 60-Day-IL. Mountcastle (hamstring) is expected to begin a rehab assignment at Triple-A Norfolk on July 22, Rich Dubroff of BaltimoreBaseball.com reports.
• Keegan Akin (Shoulder) – Status: 15-Day-IL. Akin (shoulder) will throw live batting practice at the Orioles’ complex in Florida on Monday, Roch Kubatko of MASNSports.com reports.
• Maverick Handley (Concussion) – Status: 7-Day IL. Handley (concussion) isn’t expected to be cleared to swing a bat for at least another week, Roch Kubatko of MASNSports.com reported Friday.

The Cleveland Guardians are currently healthy with no major injury concerns.

Key Player Stats

Baltimore Orioles

• Ryan O’Hearn: 0.282 AVG, 11 HR, 35 RBI
• Gunnar Henderson: 0.28 AVG, 11 HR, 32 RBI
• Jackson Holliday: 0.258 AVG, 12 HR, 38 RBI

Cleveland Guardians

• Jose Ramirez: 0.298 AVG, 19 HR, 52 RBI
• Steven Kwan: 0.285 AVG, 6 HR, 32 RBI
• Carlos Santana: 0.228 AVG, 11 HR, 42 RBI

Team Analysis

Baltimore Orioles

The Orioles possess explosive offensive potential with Ryan O’Hearn and Gunnar Henderson leading the way. Jackson Holliday adds another layer of danger, capable of producing clutch hits when it matters most.

To get back on track, Baltimore must tighten up its pitching and convert offensive pressure into actual scoring. Their key players have the tools, but execution and discipline will determine how competitive they stay in this matchup.

• Batting Average: 0.239
• Total Runs Scored: 397
• Home Runs: 111
• OPS: 0.7
• ERA: 4.98
• WHIP: 1.42

Away Record: 22-29 • Home Record: 22-25

Cleveland Guardians

Cleveland continues to surge, anchored by the offense of Jose Ramirez and supported by Steven Kwan and Carlos Santana. Their ability to deliver timely hits makes them a consistent threat, even in tight contests.

On both sides of the ball, the Guardians are showing signs of cohesion. Their blend of discipline and power could help them wear down the Orioles if the pitching remains sharp.

• Batting Average: 0.222
• Total Runs Scored: 363
• Home Runs: 101
• OPS: 0.662
• ERA: 3.98
• WHIP: 1.34

Away Record: 26-26 • Home Record: 22-24

Head-to-Head History

Cleveland Guardians 1–2 Baltimore Orioles (Last 3 games)

• 2025-04-17: CLE 2 @ BAL 6
• 2025-04-16: CLE 1 @ BAL 9
• 2025-04-15: CLE 6 @ BAL 3

Moneyline Betting Prediction

Given the current form and injury situation of the Baltimore Orioles, they’re positioned to spring an upset. The Orioles have experienced players who can rise to the occasion. The over/under trend of the Orioles suggests their knack to engage in high-scoring games, and if they can up their game, they have a fair chance to outscore the Guardians.

Back the Baltimore Orioles at +115 to deliver with confidence.

Bookmakers

Current odds sourced from: FanDuel, MyBookie.ag, LowVig.ag, BetOnline.ag, Bovada, Caesars, DraftKings, BetUS, BetMGM, BetRivers, Fanatics.

Parlamaz may earn affiliate commissions from links in this article.