MLB Prediction: San Francisco Giants vs St. Louis Cardinals (Sunday, September 7 at 02:15 PM ET)
Introduction
| Market / Trend | SF | STL |
|---|---|---|
| Moneyline | +120 | -143 |
| Total (O/U) | 8.0 | |
| Run Line | +1.5 (-177) | -1.5 (150) |
| Last 5 RPG | 7.0 | 3.0 |
| Record | 72–70 | 71–72 |
| Lines: BetMGM, BetOnline.ag, BetRivers, BetUS +7 more | ||
More MLB picks: San Francisco Giants · St. Louis Cardinals
San Francisco has surged offensively with 8.0 runs per game across its last 10 contests, a critical signal for this MLB prediction against St. Louis. The Giants’ bats have been productive, but the Cardinals’ steadier home record and ability to win tight games make them the sharper side. With both lineups showing enough scoring capacity, the total leans toward runs piling up rather than drying out.
Game Time
First pitch comes at Sunday, September 7 at 02:15 PM ET at pitcher-friendly Busch Stadium in St. Louis.
Odds & Spread Line
- San Francisco Giants: +120
- St. Louis Cardinals: -143
Total: 8
- Run Line — San Francisco Giants: +1.5 (-177)
- Run Line — St. Louis Cardinals: -1.5 (+150)
Latest Team Records
San Francisco Giants: 72-70 (Win %: 0.507)
St. Louis Cardinals: 71-72 (Win %: 0.497)
Injury Report
San Francisco Giants are missing Erik Miller (Elbow), listed as 60-Day-IL.
The St. Louis Cardinals are currently healthy with no major injury concerns.
Key Player Stats
San Francisco Giants
- Rafael Devers: 0.263 AVG, 31 HR, 99 RBI
- Willy Adames: 0.229 AVG, 27 HR, 78 RBI
- Heliot Ramos: 0.269 AVG, 16 HR, 59 RBI
St. Louis Cardinals
- Willson Contreras: 0.254 AVG, 20 HR, 78 RBI
- Alec Burleson: 0.286 AVG, 16 HR, 60 RBI
- Ivan Herrera: 0.28 AVG, 14 HR, 54 RBI
Team Analysis
San Francisco Giants
The Giants are heating up, carrying a 4-1 record in their last 5 games while averaging 7.0 runs per outing. That surge has been driven by consistent production across the order, with Rafael Devers anchoring the middle and Heliot Ramos providing timely extra-base hits. Their road record sits just above .500, showing they can translate offense into results away from home.
Over the last 10 games, San Francisco has gone 8-2 while averaging a staggering 8.0 runs per game, underscoring a lineup firing at peak efficiency. Willy Adames has been a steady power source, complementing the hot bats and adding depth to the attack. Despite their form, the matchup tilts against them given the Cardinals’ steadiness at Busch Stadium and ability to neutralize streaking opponents.
- Batting Average: 0.239
- Total Runs Scored: 615
- Home Runs: 152
- OBP: 0.314
- SLG: 0.391
- OPS: 0.706
- ERA: 3.76
- WHIP: 1.28
Away Record: 37-36 • Home Record: 35-34
Last 5 Games: 4-1 (7.0 RPG)
Last 10 Games: 8-2 (8.0 RPG)
St. Louis Cardinals
St. Louis has been steady with a 3-2 mark in its last 5 games, averaging 3.0 runs per contest. Willson Contreras remains a reliable run producer, ensuring the offense stays competitive even when scoring is modest. Their 40-34 home record provides the key edge, as Busch Stadium has consistently tilted in their favor.
Over the last 10 games, the Cardinals have posted a 6-4 record while averaging 3.5 runs, showing they can grind out wins even without explosive totals. Alec Burleson’s consistent contact and Ivan Herrera’s emerging power balance the order, giving the lineup multiple ways to generate offense. With their combination of home form and ability to close tight games, St. Louis is positioned as the sharper side in this matchup.
- Batting Average: 0.246
- Total Runs Scored: 618
- Home Runs: 136
- OBP: 0.314
- SLG: 0.382
- OPS: 0.696
- ERA: 4.28
- WHIP: 1.32
Away Record: 31-38 • Home Record: 40-34
Last 5 Games: 3-2 (3.0 RPG)
Last 10 Games: 6-4 (3.5 RPG)
Head-to-Head History
Tied 1–1 (Last 2 games)
- September 06, 2025: SF 2 @ STL 3
- September 05, 2025: SF 8 @ STL 2
Over/Under Trends
San Francisco Giants’ last 10 games have averaged 12.6 total runs, with 8 games that would have cleared today’s total of 8.
St. Louis Cardinals’ last 10 games have averaged 7.5 combined runs, with 4 games clearing the same number of 8.
Moneyline Betting Prediction
The Cardinals’ 40-34 home record, combined with their ability to pull out close wins as seen in their recent 3-2 head-to-head victory, makes them the sharper side. With Contreras, Burleson, and Herrera providing balanced production and the home field reinforcing their edge, St. Louis is the team to back with confidence.
We’re backing the St. Louis Cardinals — the read is consistent across metrics.
Over/Under Prediction
Last five form shows the St. Louis Cardinals at 3.0 RPG and the San Francisco Giants at 7.0, giving context for the number.
These teams are combining for 10.0 runs per game recently — above the posted total of 8.0. That points toward the Over 8.0.
Bookmakers
MLB Lines retrieved from: FanDuel, Fanatics, BetRivers, Caesars, LowVig.ag, BetOnline.ag, BetUS, MyBookie.ag, DraftKings, BetMGM, Bovada.
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MLB Predictions FAQ
What’s a good price range for today’s pick (Sep 07, 2025)?
We list a target price in the post. If the market moves past that number, reduce stake size or pass instead of chasing worse odds.
What do moneyline, run line, and total mean?
Moneyline is who wins the game. Run line is a spread, usually ±1.5 runs. The total (over/under) is combined runs by both teams.
How does Parlamaz make San Francisco Giants vs St. Louis Cardinals MLB predictions?
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