MLB Prediction: Houston Astros vs Los Angeles Angels (Friday, September 26 at 09:35 PM ET)
Introduction
| Market / Trend | HOU | LAA |
|---|---|---|
| Moneyline | -149 | +123 |
| Total (O/U) | 9.0 | |
| Run Line | -1.5 (110) | +1.5 (-130) |
| Last 5 RPG | 3.8 | 3.0 |
| Record | 85–74 | 71–87 |
| Lines: BetMGM, BetOnline.ag, Caesars, DraftKings +4 more | ||
More MLB picks: Houston Astros · Los Angeles Angels
Houston has stumbled with a 1-4 stretch in its last five games, averaging just 3.8 runs per outing, and that downturn sets the tone for this MLB prediction. Los Angeles has not been sharp either, but with steadier home splits and power bats like Taylor Ward and Jo Adell, the matchup tilts in their favor. With both clubs combining for under seven runs per game recently, the betting edge leans toward the Angels while keeping total expectations modest.
Game Time
Set for Friday, September 26 at 09:35 PM ET inside Angel Stadium, where carry is muted and totals stay modest typically.
Odds & Spread Line
- Houston Astros: -149
- Los Angeles Angels: +123
Total: 9
- Run Line — Houston Astros: -1.5 (+110)
- Run Line — Los Angeles Angels: +1.5 (-130)
Latest Team Records
Houston Astros: 85-74 (Win %: 0.535)
Los Angeles Angels: 71-87 (Win %: 0.449)
Injury Report
Houston Astros are missing Spencer Arrighetti (Elbow), listed as 15-Day-IL; John Rooney (Elbow), listed as 60-Day-IL; Bennett Sousa (Elbow), listed as 15-Day-IL. No other significant injuries are reported.
The Los Angeles Angels are currently healthy with no major injury concerns.
Key Player Stats
Houston Astros
- Jose Altuve: 0.263 AVG, 26 HR, 75 RBI
- Jeremy Pena: 0.304 AVG, 17 HR, 62 RBI
- Christian Walker: 0.234 AVG, 23 HR, 82 RBI
Los Angeles Angels
- Taylor Ward: 0.228 AVG, 36 HR, 103 RBI
- Jo Adell: 0.235 AVG, 36 HR, 96 RBI
- Zach Neto: 0.257 AVG, 26 HR, 62 RBI
Team Analysis
Houston Astros
The Astros enter this contest struggling, with a 1-4 mark in their last five games and only 3.8 runs per game during that span. Despite Jose Altuve’s ability to produce timely power, the lineup has been inconsistent and unable to string together high-scoring outputs. Their road record of .500 shows they are not a reliable traveling side, especially when the offense is sputtering.
Jeremy Pena has maintained a steady presence, but the lack of consistent run support limits the Astros’ upside. Christian Walker’s production has not translated into wins during this slump, and the team’s recent 4-6 stretch over 10 games makes clear that lack of rhythm. With their bats underperforming, Houston does not inspire confidence in this spot.
- Batting Average: 0.25
- Total Runs Scored: 660
- Home Runs: 172
- OBP: 0.315
- SLG: 0.396
- OPS: 0.711
- ERA: 3.89
- WHIP: 1.22
Away Record: 39-39 • Home Record: 46-35
Last 5 Games: 1-4 (3.8 RPG)
Last 10 Games: 4-6 (3.9 RPG)
Los Angeles Angels
The Angels are just 2-3 in their last five and 2-8 over their last 10, but their 3.0 RPG in that span still matches Houston Astros’ limited output. Taylor Ward’s power numbers provide a dangerous middle-of-the-order presence that can change games quickly. Playing at home, where they are steadier at 38-40, gives them the situational edge.
Jo Adell has added consistent power alongside Ward, while Zach Neto’s balanced production rounds out the lineup. Even with low-scoring trends, the Angels’ ability to manufacture key runs at home sets them up well against a Houston side that has faltered on the road. That combination makes them the sharper side in this matchup.
- Batting Average: 0.226
- Total Runs Scored: 662
- Home Runs: 220
- OBP: 0.299
- SLG: 0.398
- OPS: 0.697
- ERA: 4.86
- WHIP: 1.44
Away Record: 33-48 • Home Record: 38-40
Last 5 Games: 2-3 (3.0 RPG)
Last 10 Games: 2-8 (2.9 RPG)
Head-to-Head History
Houston Astros lead 5–3 (Last 8 games)
- September 01, 2025: LAA 3 @ HOU 8
- August 31, 2025: LAA 3 @ HOU 0
- August 30, 2025: LAA 4 @ HOU 1
- August 29, 2025: LAA 0 @ HOU 2
- June 22, 2025: HOU 8 @ LAA 7
- June 21, 2025: HOU 1 @ LAA 9
- June 20, 2025: HOU 3 @ LAA 2
- April 13, 2025: LAA 3 @ HOU 7
Over/Under Trends
Houston Astros’ last 10 games have averaged 9.0 total runs, with 5 games that would have cleared today’s total of 9.
Los Angeles Angels’ last 10 games have averaged 9.2 combined runs, with 6 games clearing the same number of 9.
Moneyline Betting Prediction
The Angels’ steadier home form and power production from Ward, Adell, and Neto give them the upper hand against a Houston squad that has dropped four of its last five with minimal scoring. With the Astros’ road performance leveling out at .500 and their offense in decline, the Angels are positioned to capitalize and secure the win.
Form and matchup create value on the Los Angeles Angels at +123.
Over/Under Prediction
In their last five, the Los Angeles Angels have produced 3.0 RPG and the Houston Astros 3.8. That output frames how this total sets up.
These teams are combining for 6.8 runs per game recently — below the posted total of 9.0. That points toward the Under 9.0.
Bookmakers
Data pulled from: BetOnline.ag, Fanatics, LowVig.ag, FanDuel, Caesars, MyBookie.ag, BetMGM, DraftKings.
Parlamaz may earn affiliate commissions from links in this article.
MLB Predictions FAQ
What do moneyline, run line, and total mean?
Moneyline is who wins the game. Run line is a spread, usually ±1.5 runs. The total (over/under) is combined runs by both teams.
How should I size my bets?
Use a consistent unit (about 1–2% of bankroll). Singles should be most of your volume. We like parlays—smart ones. Keep legs tight (2–3), cap risk to 0.25–0.5u, and pass when the price isn’t there.
