MLB Prediction: Chicago White Sox vs Washington Nationals (Friday, September 26 at 06:45 PM ET)
Introduction
| Market / Trend | CWS | WSH |
|---|---|---|
| Moneyline | +110 | -135 |
| Total (O/U) | 9.0 | |
| Run Line | +1.5 (-188) | -1.5 (155) |
| Last 5 RPG | 2.2 | 3.8 |
| Record | 58–100 | 65–94 |
| Lines: BetMGM, BetOnline.ag, BetRivers, Caesars +5 more | ||
More MLB picks: Chicago White Sox · Washington Nationals
The Chicago White Sox limp into this interleague matchup against the Washington Nationals on a brutal 0-5 skid, averaging just 2.2 runs per game across that stretch. This MLB prediction leans heavily toward Washington, whose lineup has shown steadier production and more reliable situational hitting despite inconsistencies. With Chicago’s road form collapsing and Washington Nationals’ offense anchored by James Wood and CJ Abrams, the Nationals hold the sharper betting angle in a game that profiles under the total.
Game Time
Coverage starts at Friday, September 26 at 06:45 PM ET inside Nationals Park, the mound matchup drives outcomes.
Odds & Spread Line
- Chicago White Sox: +110
- Washington Nationals: -135
Total: 9
- Run Line — Chicago White Sox: +1.5 (-188)
- Run Line — Washington Nationals: -1.5 (+155)
Latest Team Records
Chicago White Sox: 58-100 (Win %: 0.367)
Washington Nationals: 65-94 (Win %: 0.409)
Injury Report
Both teams are currently healthy with no major injury concerns.
Key Player Stats
Chicago White Sox
- Lenyn Sosa: 0.259 AVG, 21 HR, 72 RBI
- Andrew Benintendi: 0.24 AVG, 20 HR, 63 RBI
- Miguel Vargas: 0.231 AVG, 15 HR, 57 RBI
Washington Nationals
- James Wood: 0.256 AVG, 30 HR, 92 RBI
- CJ Abrams: 0.259 AVG, 18 HR, 59 RBI
- Luis Garcia Jr.: 0.251 AVG, 13 HR, 62 RBI
Team Analysis
Chicago White Sox
The White Sox enter this contest buried in a slump, going 0-5 in their last five games while producing just 2.2 runs per outing. That scoring drought highlights their lack of rhythm, and the 1-9 mark over the last 10 only reinforces an offense stuck in neutral. Lenyn Sosa has been one of the few consistent threats, but the supporting cast has not been able to sustain rallies, especially on the road where their struggles are amplified.
Andrew Benintendi and Miguel Vargas have shown flashes of power, but with such limited run production the lineup lacks balance. Their 25-53 away record emphasizes how poorly this team travels, and the inability to generate offense leaves them overmatched against even modest pitching. Given the combination of a weak road profile and current slump, Chicago projects as the less reliable side for bettors.
- Batting Average: 0.232
- Total Runs Scored: 621
- Home Runs: 157
- OBP: 0.301
- SLG: 0.371
- OPS: 0.672
- ERA: 4.25
- WHIP: 1.37
Away Record: 25-53 • Home Record: 33-48
Last 5 Games: 0-5 (2.2 RPG)
Last 10 Games: 1-9 (2.6 RPG)
Washington Nationals
The Nationals have gone 3-2 over their last five, averaging 3.8 runs per game, which gives them a steadier offensive base compared to Chicago’s collapse. James Wood has been the key run producer, providing the type of middle-order stability that can break open tight contests. At home, Washington has been more competitive, and that environment plays directly into their edge in this interleague matchup.
CJ Abrams adds another dimension with his ability to create scoring chances, while Luis Garcia Jr. has contributed timely production across the season. Even though the Nationals are only 3-7 across their last 10, their home form and ability to push across runs against weaker pitching gives them the situational advantage. With Chicago’s bats in a slump, Washington Nationals’ lineup depth makes them the clear side to trust.
- Batting Average: 0.242
- Total Runs Scored: 672
- Home Runs: 152
- OBP: 0.305
- SLG: 0.387
- OPS: 0.691
- ERA: 5.34
- WHIP: 1.45
Away Record: 34-47 • Home Record: 31-47
Last 5 Games: 3-2 (3.8 RPG)
Last 10 Games: 3-7 (3.5 RPG)
Head-to-Head History
No recent matchups between these teams in 2025.
Over/Under Trends
Chicago White Sox’s last 10 games have averaged 7.3 total runs, with 2 games that would have cleared today’s total of 9.
Washington Nationals’ last 10 games have averaged 10.0 combined runs, with 4 games clearing the same number of 9.
Moneyline Betting Prediction
Washington Nationals’ steadier recent form, stronger home splits, and lineup balance led by James Wood and CJ Abrams give them the clear edge over a Chicago team stuck in a prolonged slump. With the White Sox failing to generate runs and the Nationals showing enough consistency to capitalize, Washington is the sharper moneyline side.
Form and matchup edges favor the Washington Nationals — back them.
Over/Under Prediction
In their last five, the Washington Nationals have produced 3.8 RPG and the Chicago White Sox 2.2. That output frames how this total sets up.
These teams are combining for 6.0 runs per game recently — below the posted total of 9.0. That points toward the Under 9.0.
Bookmakers
Odds courtesy of: FanDuel, Fanatics, BetRivers, MyBookie.ag, Caesars, BetOnline.ag, LowVig.ag, DraftKings, BetMGM.
Parlamaz may earn affiliate commissions from links in this article.
MLB Predictions FAQ
How should I size my bets?
Use a consistent unit (about 1–2% of bankroll). Singles should be most of your volume. We like parlays—smart ones. Keep legs tight (2–3), cap risk to 0.25–0.5u, and pass when the price isn’t there.
What’s a good price range for today’s pick (Sep 26, 2025)?
We list a target price in the post. If the market moves past that number, reduce stake size or pass instead of chasing worse odds.
