Prediction Details

MLB Prediction: New York Mets vs Chicago Cubs (Tuesday, September 23 at 07:40 PM ET)

Introduction

Updated

NYM @ CHCNYM +102CHC -127O/U 7.5
Market / Trend NYM CHC
Moneyline +102 -127
Total (O/U) 7.5
Run Line +1.5 (-212) -1.5 (180)
Last 5 RPG 5.4 3.0
Record 80–76 88–68
Lines: BetMGM, BetOnline.ag, BetRivers, BetUS +7 more

More MLB picks: New York Mets · Chicago Cubs

The Cubs’ 46-29 home record provides a decisive edge against a Mets team that has stumbled to 31-44 on the road. This MLB prediction leans heavily on situational strength, where Chicago Cubs’ ability to grind out wins at Wrigley contrasts with New York Mets’ inconsistency away from home. With the Mets averaging 5.4 runs over their last five compared to the Cubs’ 3.0, the combined scoring environment still favors action on the total, reinforcing confidence in a Cubs victory with value on the Over.

Game Time

Starts in 18h 22m

On tap at Tuesday, September 23 at 07:40 PM ET inside Wrigley Field, totals move with the breeze.

Odds & Spread Line

  • New York Mets: +102
  • Chicago Cubs: -127

Total: 7.5

  • Run Line — New York Mets: +1.5 (-212)
  • Run Line — Chicago Cubs: -1.5 (+180)

Latest Team Records

New York Mets: 80-76 (Win %: 0.513)
Chicago Cubs: 88-68 (Win %: 0.564)

Injury Report

The New York Mets are currently healthy with no major injury concerns.

Chicago Cubs are missing Ryan Brasier (Groin), listed as 15-Day-IL; Justin Steele (Elbow), listed as 60-Day-IL.

Key Player Stats

New York Mets

  • Pete Alonso: 0.274 AVG, 37 HR, 122 RBI
  • Juan Soto: 0.267 AVG, 42 HR, 104 RBI
  • Francisco Lindor: 0.267 AVG, 28 HR, 80 RBI

Chicago Cubs

  • Michael Busch: 0.256 AVG, 30 HR, 82 RBI
  • Pete Crow-Armstrong: 0.245 AVG, 29 HR, 90 RBI
  • Seiya Suzuki: 0.242 AVG, 27 HR, 91 RBI

Team Analysis

New York Mets

The Mets have posted a 2-3 mark over their last five games, averaging 5.4 runs, which reflects inconsistency rather than dominance. Their road struggles are undeniable, with just 31 wins in 75 away contests dragging down their overall record. Pete Alonso provides reliable power, but the Mets’ road rhythm has lacked the consistency needed to trust them in this spot.

Juan Soto and Francisco Lindor have carried offensive weight, yet the team’s 4-6 record across the last ten highlights their inability to sustain momentum. Even with respectable overall run production, the Mets’ away splits suggest vulnerability against stronger home teams. Against a Cubs club that thrives in its stadium, New York Mets’ lack of road confidence is a glaring liability.

  • Batting Average: 0.25
  • Total Runs Scored: 739
  • Home Runs: 215
  • OBP: 0.327
  • SLG: 0.429
  • OPS: 0.756
  • ERA: 3.99
  • WHIP: 1.33

Away Record: 31-44 • Home Record: 49-32
Last 5 Games: 2-3 (5.4 RPG)
Last 10 Games: 4-6 (4.9 RPG)


Chicago Cubs

The Cubs’ 1-4 mark over their last five games highlights recent struggles, but their 46-29 home record offsets those concerns with a clear advantage at Wrigley. Michael Busch has delivered consistent power in the middle of the order, ensuring the Cubs remain a scoring threat despite the dip in form. That home dominance is the decisive factor separating them from a Mets team that falters away from Citi Field.

Over their last ten games, the Cubs sit at 5-5 with 3.7 runs per game, showing an average scoring pace that plays up in familiar conditions. Pete Crow-Armstrong and Seiya Suzuki have been steady contributors, and their production at home gives Chicago the stability the Mets lack on the road. With a stronger season record and superior venue splits, the Cubs are positioned to control this matchup.

  • Batting Average: 0.249
  • Total Runs Scored: 750
  • Home Runs: 209
  • OBP: 0.32
  • SLG: 0.426
  • OPS: 0.746
  • ERA: 3.82
  • WHIP: 1.18

Away Record: 42-39 • Home Record: 46-29
Last 5 Games: 1-4 (3.0 RPG)
Last 10 Games: 5-5 (3.7 RPG)


Head-to-Head History

New York Mets lead 2–1 (Last 3 games)

  • May 11, 2025: CHC 2 @ NYM 6
  • May 10, 2025: CHC 6 @ NYM 5
  • May 09, 2025: CHC 2 @ NYM 7

Over/Under Trends

New York Mets’ last 10 games have averaged 9.3 total runs, with 6 games that would have cleared today’s total of 7.5.

Chicago Cubs’ last 10 games have averaged 6.9 combined runs, with 5 games clearing the same number of 7.5.

Moneyline Betting Prediction

The Cubs’ superior home record and balanced offensive production from Michael Busch, Pete Crow-Armstrong, and Seiya Suzuki provide the decisive edge against a Mets team that falters on the road. Recent numbers show Chicago holding steadier form at Wrigley, making them the clear side to back with confidence.

This sets up cleanly for the Chicago Cubs to finish on top.

Over/Under Prediction

In their last five, the Chicago Cubs have produced 3.0 RPG and the New York Mets 5.4. That output frames how this total sets up.

These teams are combining for 8.4 runs per game recently — above the posted total of 7.5. That points toward the Over 7.5.

Bookmakers

Shop the MLB odds at: FanDuel, LowVig.ag, BetOnline.ag, Caesars, MyBookie.ag, DraftKings, Bovada, BetUS, BetMGM, Fanatics, BetRivers.

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MLB Predictions FAQ

How often are picks updated?

Daily. We update for confirmed lineups, injuries, and market moves. Check back near first pitch for final notes.

What’s a good price range for today’s pick (Sep 23, 2025)?

We list a target price in the post. If the market moves past that number, reduce stake size or pass instead of chasing worse odds.

How should I size my bets?

Use a consistent unit (about 1–2% of bankroll). Singles should be most of your volume. We like parlays—smart ones. Keep legs tight (2–3), cap risk to 0.25–0.5u, and pass when the price isn’t there.

John Tamburino

John TamburinoVerified

Lead Analyst — data-first, former college baseball.

John Tamburino grew up on travel baseball and three years of varsity basketball, then played college baseball before shifting to analytics. He still watches everything—from weekday tennis to all major league sports—and will never forget the Diamondbacks’ World Series run. At Parlamaz, John blends trusted data feeds with matchup context to find real value—no fluff, no paywalls.