MLB Prediction: San Francisco Giants vs Los Angeles Dodgers (Sunday, September 21 at 04:10 PM ET)
Introduction
| Market / Trend | SF | LAD |
|---|---|---|
| Moneyline | +185 | -227 |
| Total (O/U) | 9.0 | |
| Run Line | +1.5 (-110) | -1.5 (-110) |
| Last 5 RPG | 3.8 | 5.2 |
| Record | 76–78 | 87–67 |
| Lines: BetMGM, BetOnline.ag, BetUS, Bovada +5 more | ||
More MLB picks: San Francisco Giants · Los Angeles Dodgers
The Giants have stumbled to a 1-4 mark over their last five games, averaging just 3.8 runs per contest, while the Dodgers are rolling with a 7-3 stretch in their last 10. This matchup analysis shows a clear divide in current form, with Los Angeles maintaining offensive rhythm and San Francisco struggling to generate consistency on the road. With the Dodgers’ lineup anchored by multiple high-impact bats and a dominant head-to-head edge, this MLB prediction points squarely toward Los Angeles controlling the pace in a lower-scoring environment.
Game Time
The action begins at Sunday, September 21 at 04:10 PM ET at Dodger Stadium, a balanced venue where matchups drive scoring.
Odds & Spread Line
- San Francisco Giants: +185
- Los Angeles Dodgers: -227
Total: 9
- Run Line — San Francisco Giants: +1.5 (-110)
- Run Line — Los Angeles Dodgers: -1.5 (-110)
Latest Team Records
San Francisco Giants: 76-78 (Win %: 0.494)
Los Angeles Dodgers: 87-67 (Win %: 0.565)
Injury Report
The San Francisco Giants are currently healthy with no major injury concerns.
Los Angeles Dodgers are missing Tony Gonsolin (Elbow), listed as 60-Day-IL; Evan Phillips (Elbow), listed as 60-Day-IL.
Key Player Stats
San Francisco Giants
- Rafael Devers: 0.251 AVG, 31 HR, 104 RBI
- Willy Adames: 0.226 AVG, 28 HR, 82 RBI
- Heliot Ramos: 0.257 AVG, 18 HR, 62 RBI
Los Angeles Dodgers
- Shohei Ohtani: 0.283 AVG, 52 HR, 98 RBI
- Freddie Freeman: 0.293 AVG, 21 HR, 84 RBI
- Andy Pages: 0.281 AVG, 25 HR, 82 RBI
Team Analysis
San Francisco Giants
The Giants enter this contest with a 1-4 record over their last five games and just 2-8 over their last 10, highlighting an extended period of offensive inconsistency. Their road record sits below .500, which mirrors their struggles to produce reliable scoring away from home. Rafael Devers has been the most consistent run producer, but without broader lineup support, the team’s output remains unreliable in high-leverage spots.
Willy Adames has provided power across the season, yet the lack of situational hitting has limited the Giants’ ability to capitalize on opportunities. Heliot Ramos offers some balance, but the group’s inability to sustain rallies has been costly in recent weeks. Against a Dodgers team that thrives at home, San Francisco Giants’ current form leaves them needing a significant turnaround to threaten the hosts.
- Batting Average: 0.235
- Total Runs Scored: 666
- Home Runs: 163
- OBP: 0.311
- SLG: 0.385
- OPS: 0.696
- ERA: 3.84
- WHIP: 1.3
Away Record: 38-42 • Home Record: 38-37
Last 5 Games: 1-4 (3.8 RPG)
Last 10 Games: 2-8 (3.7 RPG)
Los Angeles Dodgers
The Dodgers have surged to a 4-1 mark in their last five and 7-3 in their last 10, consistently outscoring opponents with a 6.4 RPG clip across that stretch. At home, their 52-28 record points to why they’re one of the league’s most reliable teams in their own ballpark. Shohei Ohtani’s power production leads the way, giving Los Angeles the ability to change games quickly.
Freddie Freeman’s consistency in driving in runs complements Ohtani’s explosiveness, while Andy Pages has added another layer of balance to the order. This trio has kept the Dodgers’ offense steady, and paired with their strong home dominance, it creates a decisive edge over San Francisco. Their current rhythm positions them as the superior side, with both form and matchup history firmly on their side.
- Batting Average: 0.254
- Total Runs Scored: 786
- Home Runs: 228
- OBP: 0.329
- SLG: 0.44
- OPS: 0.769
- ERA: 4.02
- WHIP: 1.27
Away Record: 36-39 • Home Record: 52-28
Last 5 Games: 4-1 (5.2 RPG)
Last 10 Games: 7-3 (6.4 RPG)
Head-to-Head History
Los Angeles Dodgers lead 7–1 (Last 8 games)
- September 20, 2025: SF 5 @ LAD 7
- September 19, 2025: SF 3 @ LAD 6
- September 18, 2025: SF 1 @ LAD 2
- September 14, 2025: LAD 10 @ SF 2
- September 13, 2025: LAD 13 @ SF 7
- September 12, 2025: LAD 1 @ SF 5
- July 13, 2025: LAD 5 @ SF 2
- July 12, 2025: LAD 2 @ SF 1
Over/Under Trends
San Francisco Giants’ last 10 games have averaged 9.6 total runs, with 4 games that would have cleared today’s total of 9.
Los Angeles Dodgers’ last 10 games have averaged 10.2 combined runs, with 5 games clearing the same number of 9.
Moneyline Betting Prediction
The Dodgers’ 52-28 home record combined with their 7-1 dominance over the Giants in recent meetings demonstrates a decisive edge that aligns with their current 7-3 stretch. With Ohtani, Freeman, and Pages consistently producing, Los Angeles has both the lineup depth and situational strength to overpower a San Francisco team that has stumbled on the road.
We’re backing the Los Angeles Dodgers to handle business.
Over/Under Prediction
Last five form shows the Los Angeles Dodgers at 5.2 RPG and the San Francisco Giants at 3.8, giving context for the number.
These teams are combining for 9.0 runs per game recently — right around the posted total of 9.0. That points toward the Under 9.0.
Bookmakers
These lines come from: FanDuel, Fanatics, Caesars, LowVig.ag, BetOnline.ag, DraftKings.
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MLB Predictions FAQ
How does Parlamaz make San Francisco Giants vs Los Angeles Dodgers MLB predictions?
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What’s a good price range for today’s pick (Sep 21, 2025)?
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