MLB Prediction: San Diego Padres vs Chicago White Sox (Friday, September 19 at 07:40 PM ET)
Introduction
| Market / Trend | SD | CWS |
|---|---|---|
| Moneyline | -175 | +145 |
| Total (O/U) | 8.0 | |
| Run Line | -1.5 (-101) | +1.5 (-118) |
| Last 5 RPG | 6.2 | 2.4 |
| Record | 83–70 | 57–96 |
| Lines: BetMGM, BetOnline.ag, BetRivers, BetUS +7 more | ||
More MLB picks: San Diego Padres · Chicago White Sox
San Diego enters this interleague matchup analysis against the Chicago White Sox with steadier production, averaging 6.2 runs per game across their last five contests compared to Chicago’s 2.4. That scoring split is decisive, as the Padres maintain a winning record while the White Sox remain stuck in a deep losing stretch. This MLB prediction leans heavily toward San Diego Padres’ ability to sustain offensive pressure and exploit a vulnerable Chicago lineup that has failed to generate momentum.
Game Time
Set for Friday, September 19 at 07:40 PM ET inside Guaranteed Rate Field, run creation trends higher.
Odds & Spread Line
- San Diego Padres: -175
- Chicago White Sox: +145
Total: 8
- Run Line — San Diego Padres: -1.5 (-101)
- Run Line — Chicago White Sox: +1.5 (-118)
Latest Team Records
San Diego Padres: 83-70 (Win %: 0.542)
Chicago White Sox: 57-96 (Win %: 0.373)
Injury Report
The San Diego Padres are currently healthy with no major injury concerns.
Chicago White Sox are missing Martin Perez (Undisclosed), listed as Day-To-Day.
Key Player Stats
San Diego Padres
- Manny Machado: 0.279 AVG, 26 HR, 92 RBI
- Ramon Laureano: 0.285 AVG, 24 HR, 76 RBI
- Fernando Tatis Jr.: 0.266 AVG, 22 HR, 65 RBI
Chicago White Sox
- Lenyn Sosa: 0.261 AVG, 20 HR, 70 RBI
- Andrew Benintendi: 0.24 AVG, 20 HR, 62 RBI
- Mike Tauchman: 0.264 AVG, 9 HR, 40 RBI
Team Analysis
San Diego Padres
The Padres’ 3-2 mark in their last five games, paired with 6.2 runs per game, highlights a lineup that is executing efficiently. Their road record remains under .500, but the recent offensive surge demonstrates that they are overcoming those splits with timely hitting. Manny Machado’s consistent production provides a backbone to an offense that can overwhelm weaker pitching staffs.
Over the last 10 games, San Diego has gone 5-5 with 4.2 runs per game, showing a balanced profile that trends upward when compared to Chicago’s offensive struggles. Ramon Laureano and Fernando Tatis Jr. add depth, creating multiple threats in the order and forcing opponents to pitch carefully. With stable run creation and a deeper lineup, the Padres are positioned to take advantage of a team that has been unable to sustain scoring at home.
- Batting Average: 0.252
- Total Runs Scored: 651
- Home Runs: 140
- OBP: 0.322
- SLG: 0.39
- OPS: 0.711
- ERA: 3.67
- WHIP: 1.2
Away Record: 36-42 • Home Record: 47-28
Last 5 Games: 3-2 (6.2 RPG)
Last 10 Games: 5-5 (4.2 RPG)
Chicago White Sox
The White Sox enter off a 0-5 stretch while averaging just 2.4 runs per game, signaling a lineup in a slump. Even with Lenyn Sosa showing flashes of power, the lack of sustained production across the order leaves them unable to pressure opponents effectively. Their season record speaks to long-term inconsistency that has eroded confidence in their ability to compete against higher-caliber lineups.
Across the last 10 games, Chicago has gone 3-7 with 3.3 runs per game, further underlining a lack of offensive rhythm. Andrew Benintendi and Mike Tauchman provide supplementary support, but the collective struggles at the plate overshadow individual contributions. With a 32-46 home record, the White Sox have failed to leverage home field, and that weakness makes them vulnerable against a San Diego team with superior offensive balance.
- Batting Average: 0.233
- Total Runs Scored: 609
- Home Runs: 154
- OBP: 0.302
- SLG: 0.373
- OPS: 0.675
- ERA: 4.23
- WHIP: 1.36
Away Record: 25-50 • Home Record: 32-46
Last 5 Games: 0-5 (2.4 RPG)
Last 10 Games: 3-7 (3.3 RPG)
Head-to-Head History
No recent matchups between these teams in 2025.
Over/Under Trends
San Diego Padres’ last 10 games have averaged 8.2 total runs, with 4 games that would have cleared today’s total of 8.
Chicago White Sox’s last 10 games have averaged 7.3 combined runs, with 4 games clearing the same number of 8.
Moneyline Betting Prediction
San Diego Padres’ balanced scoring profile and recent 3-2 stretch at 6.2 runs per game make them the stronger side against a Chicago team stuck in a 0-5 skid. With multiple offensive threats in the order and superior overall consistency, the Padres hold the decisive edge in this matchup and are the correct moneyline selection.
Markets point to the San Diego Padres as the correct angle.
Over/Under Prediction
Recent five-game scoring: the Chicago White Sox are at 2.4 RPG and the San Diego Padres at 6.2 — a useful baseline against the total.
These teams are combining for 8.6 runs per game recently — above the posted total of 8.0. That points toward the Over 8.0.
Bookmakers
These lines come from: FanDuel, MyBookie.ag, LowVig.ag, BetOnline.ag, Caesars, DraftKings, BetUS, BetMGM, Bovada, BetRivers, Fanatics.
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MLB Predictions FAQ
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