MLB Prediction: Chicago White Sox vs Cleveland Guardians (Saturday, September 13 at 06:10 PM ET)
Introduction
| Market / Trend | CWS | CLE |
|---|---|---|
| Moneyline | +150 | -185 |
| Total (O/U) | 8.0 | |
| Run Line | +1.5 (-155) | -1.5 (130) |
| Last 5 RPG | 4.2 | 4.4 |
| Record | 57–91 | 76–71 |
| Lines: BetMGM, BetOnline.ag, BetRivers, BetUS +7 more | ||
More MLB picks: Chicago White Sox · Cleveland Guardians
Cleveland Guardians’ 8-2 surge across their last 10 contests underlines a team peaking at the right time, while Chicago’s 7-3 stretch has been built largely on streaky scoring. This matchup analysis highlights the Guardians’ ability to control games both at home and in head-to-head meetings, where they’ve won six of the last eight. With both lineups averaging over 4 runs per game in their recent five, the data points to Cleveland as the sharper side and a game script that favors higher scoring than the posted total suggests.
Game Time
Game time: Saturday, September 13 at 06:10 PM ET at Progressive Field, conditions can swing totals.
Odds & Spread Line
- Chicago White Sox: +150
- Cleveland Guardians: -185
Total: 8
- Run Line — Chicago White Sox: +1.5 (-155)
- Run Line — Cleveland Guardians: -1.5 (+130)
Latest Team Records
Chicago White Sox: 57-91 (Win %: 0.385)
Cleveland Guardians: 76-71 (Win %: 0.517)
Injury Report
Chicago White Sox are missing Max Stassi (Undisclosed), listed as Day-To-Day; Brooks Baldwin (Hip), listed as Day-To-Day.
The Cleveland Guardians are currently healthy with no major injury concerns.
Key Player Stats
Chicago White Sox
- Lenyn Sosa: 0.265 AVG, 20 HR, 67 RBI
- Andrew Benintendi: 0.248 AVG, 19 HR, 60 RBI
- Mike Tauchman: 0.274 AVG, 8 HR, 39 RBI
Cleveland Guardians
- Jose Ramirez: 0.285 AVG, 28 HR, 77 RBI
- Kyle Manzardo: 0.24 AVG, 26 HR, 67 RBI
- Steven Kwan: 0.276 AVG, 10 HR, 48 RBI
Team Analysis
Chicago White Sox
The White Sox enter with a 57-91 record and have gone 3-2 over their last five, showing some short-term stability despite an otherwise difficult campaign. Their offense has been inconsistent, often leaning on Lenyn Sosa to provide power but lacking consistent RBI production across the order. A 25-48 road record highlights their struggles away from home, where scoring output has not traveled well.
Andrew Benintendi has chipped in timely hits, but overall run support has been unreliable when the lineup stretches thin. Mike Tauchman’s recent contributions have added some depth, yet the team’s rhythm still wavers game to game. Against a Guardians team thriving at home, the White Sox must overcome their uneven road form to compete.
- Batting Average: 0.236
- Total Runs Scored: 597
- Home Runs: 150
- OBP: 0.305
- SLG: 0.378
- OPS: 0.683
- ERA: 4.22
- WHIP: 1.36
Away Record: 25-48 • Home Record: 32-43
Last 5 Games: 3-2 (4.2 RPG)
Last 10 Games: 7-3 (5.5 RPG)
Cleveland Guardians
The Guardians’ 76-71 record reflects a team that has found rhythm late in the season, winning four of their last five while averaging 4.4 runs in that span. Jose Ramirez continues to anchor their lineup, driving in runs consistently and forcing pitchers to attack differently. Their 39-34 home record shows they protect their own field well, a key factor when assessing their betting profile.
Kyle Manzardo’s power output has added another layer of production, giving Cleveland more balance alongside Steven Kwan’s steady contact skills. With an 8-2 record across the last 10 games, the Guardians are playing with confidence that translates directly into betting value. This form, combined with their proven edge in head-to-head play, makes them the clear side to back at Progressive Field.
- Batting Average: 0.225
- Total Runs Scored: 570
- Home Runs: 149
- OBP: 0.296
- SLG: 0.369
- OPS: 0.666
- ERA: 3.86
- WHIP: 1.3
Away Record: 37-37 • Home Record: 39-34
Last 5 Games: 4-1 (4.4 RPG)
Last 10 Games: 8-2 (4.4 RPG)
Head-to-Head History
Cleveland Guardians lead 6–2 (Last 8 games)
- September 12, 2025: CHW 0 @ CLE 4
- August 10, 2025: CLE 4 @ CHW 6
- August 09, 2025: CLE 3 @ CHW 1
- August 08, 2025: CLE 9 @ CHW 5
- July 13, 2025: CLE 6 @ CHW 5
- July 12, 2025: CLE 6 @ CHW 2
- July 11, 2025: CLE 4 @ CHW 5
- July 11, 2025: CLE 4 @ CHW 2
Over/Under Trends
Chicago White Sox’s last 10 games have averaged 9.9 total runs, with 6 games that would have cleared today’s total of 8.
Cleveland Guardians’ last 10 games have averaged 6.1 combined runs, with 2 games clearing the same number of 8.
Moneyline Betting Prediction
Cleveland Guardians’ 8-2 stretch, combined with a 39-34 home mark and dominance in recent head-to-heads, positions them as the stronger side. With Jose Ramirez leading a balanced lineup and support from Kyle Manzardo and Steven Kwan, the Guardians’ offensive consistency is enough to outpace Chicago’s road inefficiency and secure another win.
Confidence sits with the Cleveland Guardians based on recent profiles.
Over/Under Prediction
In their last five, the Cleveland Guardians have produced 4.4 RPG and the Chicago White Sox 4.2. That output frames how this total sets up.
These teams are combining for 8.6 runs per game recently — above the posted total of 8.0. That points toward the Over 8.0.
Bookmakers
Odds courtesy of: BetOnline.ag, LowVig.ag, Caesars, DraftKings, MyBookie.ag, Bovada, FanDuel, BetMGM, Fanatics, BetUS, BetRivers.
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MLB Predictions FAQ
What’s a good price range for today’s pick (Sep 13, 2025)?
We list a target price in the post. If the market moves past that number, reduce stake size or pass instead of chasing worse odds.
How does Parlamaz make Chicago White Sox vs Cleveland Guardians MLB predictions?
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