Prediction Details

MLB Prediction: Pittsburgh Pirates vs St. Louis Cardinals (Wednesday, August 27 at 07:45 PM ET)

Introduction

Updated

PIT @ STLPIT +155STL -189O/U 7.5
Market / Trend PIT STL
Moneyline +155 -189
Total (O/U) 7.5
Run Line +1.5 (-140) -1.5 (115)
Last 5 RPG 6.4 5.0
Record 57–75 65–67
Lines: BetMGM, Caesars, FanDuel, Fanatics +1 more

More MLB picks: Pittsburgh Pirates · St. Louis Cardinals

The Pirates have surged with a 4-1 mark in their last five, averaging 6.4 runs per game, but this matchup analysis points to the Cardinals as the sharper betting angle. St. Louis has maintained steadier offensive output at 5.4 runs across their last 10, and their lineup depth is better built for consistency. With the Cardinals’ home record showing stability and their recent games trending high-scoring, this MLB prediction leans toward both a home win and the Over.

Game Time

Starts in 18h 20m

First pitch comes at Wednesday, August 27 at 07:45 PM ET at pitcher-friendly Busch Stadium in St. Louis.

Odds & Spread Line

  • Pittsburgh Pirates: +155
  • St. Louis Cardinals: -189

Total: 7.5

  • Run Line — Pittsburgh Pirates: +1.5 (-140)
  • Run Line — St. Louis Cardinals: -1.5 (+115)

Latest Team Records

Pittsburgh Pirates: 57-75 (Win %: 0.432)
St. Louis Cardinals: 65-67 (Win %: 0.492)

Injury Report

Both teams are currently healthy with no major injury concerns.

Key Player Stats

Pittsburgh Pirates

  • Bryan Reynolds: 0.246 AVG, 14 HR, 65 RBI
  • Andrew McCutchen: 0.241 AVG, 12 HR, 47 RBI
  • Tommy Pham: 0.265 AVG, 7 HR, 38 RBI

St. Louis Cardinals

  • Alec Burleson: 0.291 AVG, 16 HR, 60 RBI
  • Willson Contreras: 0.261 AVG, 19 HR, 72 RBI
  • Ivan Herrera: 0.279 AVG, 10 HR, 47 RBI

Team Analysis

Pittsburgh Pirates

The Pirates have shown a recent spark with a 4-1 record over their last five games, producing 6.4 runs per contest during that stretch. That surge has been powered by timely hitting from Bryan Reynolds and Andrew McCutchen, who have each delivered key run production. However, their road form remains a glaring weakness, with just 19 wins away from home, limiting confidence in sustainability against stronger competition.

Tommy Pham has added stability to the lineup, but the Pirates’ season-long inconsistency is reflected in their overall losing record. While their last 10 games at 6-4 show improvement, the Pirates have struggled to carry momentum when traveling, which is a critical factor here. Against a Cardinals side that thrives at Busch Stadium, Pittsburgh Pirates’ offense is likely to regress back toward its season averages.

  • Batting Average: 0.234
  • Total Runs Scored: 473
  • Home Runs: 96
  • OBP: 0.306
  • SLG: 0.352
  • OPS: 0.658
  • ERA: 3.96
  • WHIP: 1.22

Away Record: 19-45 • Home Record: 39-30
Last 5 Games: 4-1 (6.4 RPG)
Last 10 Games: 6-4 (4.6 RPG)


St. Louis Cardinals

The Cardinals’ offense has been steady, averaging 5.4 runs across their last 10 games, even while going 4-6 in that span. Willson Contreras has been a reliable run producer, while Ivan Herrera adds balance to the lower half of the order. With a 36-31 home record, St. Louis has consistently leveraged Busch Stadium to secure wins, giving them a decisive edge.

Alec Burleson’s ability to generate contact and drive in runs strengthens an already balanced lineup. Despite a 2-3 mark in their last five, the Cardinals’ run production remains strong at 5.0 per game, which matters more for betting context than win-loss variance. Their combination of home-field stability and offensive depth makes them the superior side in this matchup.

  • Batting Average: 0.249
  • Total Runs Scored: 580
  • Home Runs: 125
  • OBP: 0.317
  • SLG: 0.385
  • OPS: 0.703
  • ERA: 4.31
  • WHIP: 1.31

Away Record: 29-37 • Home Record: 36-31
Last 5 Games: 2-3 (5.0 RPG)
Last 10 Games: 4-6 (5.4 RPG)


Head-to-Head History

Tied 4–4 (Last 8 games)

  • August 26, 2025: PIT 8 @ STL 3
  • August 25, 2025: PIT 6 @ STL 7
  • July 02, 2025: STL 0 @ PIT 5
  • July 01, 2025: STL 0 @ PIT 1
  • June 30, 2025: STL 0 @ PIT 7
  • May 07, 2025: PIT 0 @ STL 5
  • May 06, 2025: PIT 1 @ STL 2
  • May 05, 2025: PIT 3 @ STL 6

Over/Under Trends

Pittsburgh Pirates’ last 10 games have averaged 7.4 total runs, with 4 games that would have cleared today’s total of 7.5.

St. Louis Cardinals’ last 10 games have averaged 12.2 combined runs, with 10 games clearing the same number of 7.5.

Moneyline Betting Prediction

The Cardinals’ steady offensive production at home, combined with their 36-31 record at Busch Stadium, makes them the superior side against an inconsistent Pirates road team. With Willson Contreras and Alec Burleson anchoring a lineup that consistently drives in runs, the Cardinals are positioned to control this game from start to finish.

We’re backing the St. Louis Cardinals to handle business.

Over/Under Prediction

Recent five-game scoring: the St. Louis Cardinals are at 5.0 RPG and the Pittsburgh Pirates at 6.4 — a useful baseline against the total.

These teams are combining for 11.4 runs per game recently — above the posted total of 7.5. That points toward the Over 7.5.

Bookmakers

These lines come from: FanDuel, MyBookie.ag, Fanatics, Caesars, BetMGM.

Parlamaz may earn affiliate commissions from links in this article.

MLB Predictions FAQ

What do moneyline, run line, and total mean?

Moneyline is who wins the game. Run line is a spread, usually ±1.5 runs. The total (over/under) is combined runs by both teams.

How does Parlamaz make Pittsburgh Pirates vs St. Louis Cardinals MLB predictions?

We use trusted data feeds and real-time odds to model each matchup. We weight the numbers that move lines—team form, matchup history, injuries, park factors, totals trends, and betting momentum—then compare our price to the market to find value. All signal, no noise. No paywalls.

How often are picks updated?

Daily. We update for confirmed lineups, injuries, and market moves. Check back near first pitch for final notes.

John Tamburino

John TamburinoVerified

Lead Analyst — data-first, former college baseball.

John Tamburino grew up on travel baseball and three years of varsity basketball, then played college baseball before shifting to analytics. He still watches everything—from weekday tennis to UFC—and will never forget the Diamondbacks’ 2001 run. At Parlamaz, John blends trusted data feeds with matchup context to find real value—no fluff, no paywalls.