MLB Prediction: San Diego Padres vs Seattle Mariners (Wednesday, August 27 at 04:10 PM ET)
Introduction
| Market / Trend | SD | SEA |
|---|---|---|
| Moneyline | +121 | -133 |
| Total (O/U) | 8.0 | |
| Run Line | +1.5 (-188) | -1.5 (155) |
| Last 5 RPG | 4.4 | 6.0 |
| Record | 74–58 | 71–61 |
| Lines: BetMGM, BetOnline.ag, BetRivers, BetUS +7 more | ||
More MLB picks: San Diego Padres · Seattle Mariners
Seattle has taken four of the last five against San Diego, and that head-to-head edge frames this interleague MLB prediction with conviction. The Padres are averaging 5.0 runs per game over their last 10, while the Mariners have surged to 6.0 per game in their last five, signaling a matchup tilted toward offense. With the Mariners’ home form proving reliable and San Diego Padres’ away record less convincing, the numbers point directly toward Seattle and a higher-scoring contest.
Game Time
The action begins at Wednesday, August 27 at 04:10 PM ET at T-Mobile Park, pitcher-friendly by profile.
Odds & Spread Line
- San Diego Padres: +121
- Seattle Mariners: -133
Total: 8
- Run Line — San Diego Padres: +1.5 (-188)
- Run Line — Seattle Mariners: -1.5 (+155)
Latest Team Records
San Diego Padres: 74-58 (Win %: 0.561)
Seattle Mariners: 71-61 (Win %: 0.538)
Injury Report
Both teams are currently healthy with no major injury concerns.
Key Player Stats
San Diego Padres
- Manny Machado: 0.289 AVG, 21 HR, 78 RBI
- Ramon Laureano: 0.297 AVG, 20 HR, 62 RBI
- Ryan O’Hearn: 0.278 AVG, 16 HR, 53 RBI
Seattle Mariners
- Cal Raleigh: 0.247 AVG, 50 HR, 107 RBI
- Eugenio Suarez: 0.234 AVG, 40 HR, 98 RBI
- Julio Rodriguez: 0.259 AVG, 25 HR, 73 RBI
Team Analysis
San Diego Padres
The Padres’ 3-2 mark in their last five games reflects a team playing steady but not overwhelming baseball, with 4.4 runs per game in that stretch. Their road record sits below .500, indicating a vulnerability when away from home that becomes critical in this matchup. Manny Machado is producing consistently, but the team’s overall rhythm has leaned more toward grinding out wins than dominating opponents.
Over their last 10 games, San Diego has averaged 5.0 runs per contest, showing signs of offensive reliability but not the explosive ceiling that Seattle has displayed. Ramon Laureano has been a steady contributor, while Ryan O’Hearn adds balance to the middle order, but the Padres still lack the sustained firepower that can tilt games on the road. Their pitching metrics remain solid, yet the Mariners’ home advantage and power profile create a sharper betting edge against them.
- Batting Average: 0.251
- Total Runs Scored: 554
- Home Runs: 115
- OBP: 0.321
- SLG: 0.385
- OPS: 0.706
- ERA: 3.57
- WHIP: 1.19
Away Record: 32-36 • Home Record: 43-22
Last 5 Games: 3-2 (4.4 RPG)
Last 10 Games: 6-4 (5.0 RPG)
Seattle Mariners
The Mariners have been more volatile in their last 10 with a 3-7 record, yet their offense has surged to 6.0 runs per game across the last five, proving they can overwhelm opponents when the bats connect. At home, their 40-27 mark reinforces their reliability at this venue, where power bats like Cal Raleigh thrive. That combination of recent scoring spike and venue strength makes them the stronger betting side.
Eugenio Suarez has been a steady source of power, while Julio Rodriguez adds dynamic production that stresses opposing pitchers. Despite the recent losing stretch, the Mariners’ ability to generate nearly 11 combined runs per game across their last 10 contests shows they are playing in higher-scoring environments. With their lineup producing at home and the Padres struggling away, Seattle enters with the offensive upside to dictate the pace.
- Batting Average: 0.242
- Total Runs Scored: 606
- Home Runs: 188
- OBP: 0.318
- SLG: 0.411
- OPS: 0.729
- ERA: 3.96
- WHIP: 1.26
Away Record: 31-35 • Home Record: 40-27
Last 5 Games: 3-2 (6.0 RPG)
Last 10 Games: 3-7 (4.7 RPG)
Head-to-Head History
Seattle Mariners lead 4–1 (Last 5 games)
- August 26, 2025: SD 7 @ SEA 6
- August 25, 2025: SD 6 @ SEA 9
- May 18, 2025: SEA 6 @ SD 1
- May 17, 2025: SEA 4 @ SD 1
- May 16, 2025: SEA 5 @ SD 1
Over/Under Trends
San Diego Padres’ last 10 games have averaged 9.0 total runs, with 6 games that would have cleared today’s total of 8.
Seattle Mariners’ last 10 games have averaged 10.7 combined runs, with 7 games clearing the same number of 8.
Moneyline Betting Prediction
Seattle Mariners’ 40-27 home record paired with a consistent scoring lift from Cal Raleigh and Julio Rodriguez creates a decisive edge over a Padres team that has underperformed away from home. With four wins in the last five meetings and a recent surge to six runs per game, Seattle Mariners’ offensive profile and situational strength make them the clear moneyline side.
Data supports the Seattle Mariners as the right side.
Over/Under Prediction
In their last five, the Seattle Mariners have produced 6.0 RPG and the San Diego Padres 4.4. That output frames how this total sets up.
These teams are combining for 10.4 runs per game recently — above the posted total of 8.0. That points toward the Over 8.0.
Bookmakers
These lines come from: FanDuel, BetOnline.ag, LowVig.ag, Caesars, DraftKings, MyBookie.ag, Bovada, Fanatics, BetMGM, BetRivers, BetUS.
Parlamaz may earn affiliate commissions from links in this article.
MLB Predictions FAQ
What’s a good price range for today’s pick (Aug 27, 2025)?
We list a target price in the post. If the market moves past that number, reduce stake size or pass instead of chasing worse odds.
How often are picks updated?
Daily. We update for confirmed lineups, injuries, and market moves. Check back near first pitch for final notes.
