Prediction Details

MLB Prediction: San Diego Padres vs Seattle Mariners (Monday, August 25 at 09:40 PM ET)

Introduction

Updated

SD @ SEASD +106SEA -133O/U 7.5
Market / Trend SD SEA
Moneyline +106 -133
Total (O/U) 7.5
Run Line +1.5 (-196) -1.5 (162)
Last 5 RPG 5.0 4.2
Record 74–56 69–61
Lines: BetRivers, FanDuel, MyBookie.ag

More MLB picks: San Diego Padres · Seattle Mariners

Seattle Mariners’ recent 3–0 dominance over San Diego provides a clear signal for this interleague MLB prediction, and the Mariners’ last 10 games averaging 10.7 combined runs reinforce how aggressively they’ve been scoring. The Padres have surged to a 4-1 mark in their last five, but their 31-35 road record highlights vulnerability away from home. With Seattle Mariners’ lineup consistently producing extra-base damage and San Diego Padres’ offense needing to prove it travels, this matchup analysis points directly to the Mariners and a high-scoring game environment.

Game Time

Starts in 25h 38m

This one goes at Monday, August 25 at 09:40 PM ET inside T-Mobile Park, unders stay live.

Odds & Spread Line

  • San Diego Padres: +106
  • Seattle Mariners: -133

Total: 7.5

  • Run Line — San Diego Padres: +1.5 (-196)
  • Run Line — Seattle Mariners: -1.5 (+162)

Latest Team Records

San Diego Padres: 74-56 (Win %: 0.569)
Seattle Mariners: 69-61 (Win %: 0.531)

Injury Report

Both teams are currently healthy with no major injury concerns.

Key Player Stats

San Diego Padres

  • Manny Machado: 0.292 AVG, 21 HR, 78 RBI
  • Ramon Laureano: 0.301 AVG, 19 HR, 61 RBI
  • Ryan O’Hearn: 0.282 AVG, 16 HR, 53 RBI

Seattle Mariners

  • Cal Raleigh: 0.244 AVG, 47 HR, 102 RBI
  • Eugenio Suarez: 0.237 AVG, 40 HR, 98 RBI
  • Julio Rodriguez: 0.259 AVG, 25 HR, 71 RBI

Team Analysis

San Diego Padres

The Padres enter with a solid 74-56 record and have gone 4-1 in their last five, averaging 5.0 runs per game during that stretch. This recent surge shows offensive rhythm, with Manny Machado anchoring the lineup and Ramon Laureano providing steady production. However, their inconsistency over the last 10 games at just 5-5 with 3.9 RPG lays bare how their scoring has fluctuated and why they remain vulnerable away from home.

San Diego Padres’ 31-35 road record is a clear weakness, and despite Ryan O’Hearn’s steady contributions, the team has not consistently translated home success to road environments. Their lineup has shown bursts of production lately, but the Mariners’ pitching environment and Seattle Mariners’ recent head-to-head dominance cast serious doubt on whether that momentum carries over. The Padres’ outlook is competitive, yet situational edges tilt against them in this setting.

  • Batting Average: 0.252
  • Total Runs Scored: 546
  • Home Runs: 110
  • OBP: 0.322
  • SLG: 0.384
  • OPS: 0.706
  • ERA: 3.5
  • WHIP: 1.19

Away Record: 31-35 • Home Record: 43-22
Last 5 Games: 4-1 (5.0 RPG)
Last 10 Games: 5-5 (3.9 RPG)


Seattle Mariners

Seattle holds a 69-61 record and while their last five games stand at 2-3, they’ve averaged a respectable 4.2 RPG in that span. Cal Raleigh’s power output has been a decisive factor, and Eugenio Suarez’s ability to drive in runs keeps their lineup dangerous. Their 39-26 home record is a critical strength, showing that this team thrives at T-Mobile Park.

Over the last 10 games, Seattle has gone 3-7 but still averaged 4.6 RPG, proving their bats are not the issue. Julio Rodriguez adds another layer of offensive consistency, and the Mariners’ ability to generate extra-base production at home has consistently pressured visiting pitchers. Given their home dominance and recent head-to-head sweep of San Diego, Seattle Mariners’ profile is far stronger in this matchup.

  • Batting Average: 0.241
  • Total Runs Scored: 586
  • Home Runs: 184
  • OBP: 0.317
  • SLG: 0.409
  • OPS: 0.726
  • ERA: 3.95
  • WHIP: 1.26

Away Record: 31-35 • Home Record: 39-26
Last 5 Games: 2-3 (4.2 RPG)
Last 10 Games: 3-7 (4.6 RPG)


Head-to-Head History

Seattle Mariners lead 3–0 (Last 3 games)

  • May 18, 2025: SEA 6 @ SD 1
  • May 17, 2025: SEA 4 @ SD 1
  • May 16, 2025: SEA 5 @ SD 1

Over/Under Trends

San Diego Padres’ last 10 games have averaged 7.3 total runs, with 4 games that would have cleared today’s total of 7.5.

Seattle Mariners’ last 10 games have averaged 10.7 combined runs, with 7 games clearing the same number of 7.5.

Moneyline Betting Prediction

The Mariners’ 39-26 home record, combined with their sweep of San Diego in the last three meetings, lays bare why Seattle is the superior side. With Cal Raleigh and Eugenio Suarez driving run production and Julio Rodriguez adding balance, their offense is better built to sustain scoring at this venue. San Diego Padres’ road struggles and inconsistent recent scoring make them a step behind in this matchup, leaving Seattle as the team positioned to control the outcome.

We’re backing the Seattle Mariners to handle business.

Over/Under Prediction

In their last five, the Seattle Mariners have produced 4.2 RPG and the San Diego Padres 5.0. That output frames how this total sets up.

These teams are combining for 9.2 runs per game recently — above the posted total of 7.5. That points toward the Over 7.5.

Bookmakers

You’ll find these markets at: FanDuel, MyBookie.ag, BetRivers.

Parlamaz may earn affiliate commissions from links in this article.

MLB Predictions FAQ

How does Parlamaz make San Diego Padres vs Seattle Mariners MLB predictions?

We use trusted data feeds and real-time odds to model each matchup. We weight the numbers that move lines—team form, matchup history, injuries, park factors, totals trends, and betting momentum—then compare our price to the market to find value. All signal, no noise. No paywalls.

How should I size my bets?

Use a consistent unit (about 1–2% of bankroll). Singles should be most of your volume. We like parlays—smart ones. Keep legs tight (2–3), cap risk to 0.25–0.5u, and pass when the price isn’t there.

John Tamburino

John TamburinoVerified

Lead Analyst — data-first, former college baseball.

John Tamburino grew up on travel baseball and three years of varsity basketball, then played college baseball before shifting to analytics. He still watches everything—from weekday tennis to UFC—and will never forget the Diamondbacks’ 2001 run. At Parlamaz, John blends trusted data feeds with matchup context to find real value—no fluff, no paywalls.