Introduction

The Houston Astros are set to lock horns with the Arizona Diamondbacks in this much-anticipated American League and National League showdown. It’s going to be an intense mashup, as both look to secure their positions in the league. Baseball fans are bracing themselves for a game charged with talent and strategy, and bettors are already playing the odds.

Game Time

The game kicks off at Monday, July 21 at 09:40 PM ET under the retractable roof at Chase Field, a neutral-hitting park.

Moneyline Odds

Houston Astros: +130
Arizona Diamondbacks: -154
Over/Under Line: 9.0

Latest Team Records

Houston Astros have a record of 56-42 with a win percentage of 0.571, while the Arizona Diamondbacks hold a record of 49-50 with a win percentage of 0.495.

Injury Report

Key injuries for the Houston Astros include:

• Shawn Dubin (Forearm) – Status: 15-Day-IL. Dubin (forearm) has resumed throwing from flat ground in Florida, MLB.com reports.
• Zach Dezenzo (Hand) – Status: 60-Day-IL. Dezenzo (hand) has not resumed hitting since being placed on the injured list June 3, Matt Kawahara of the Houston Chronicle reports.

Key injuries for the Arizona Diamondbacks include:

• Gabriel Moreno (Finger) – Status: 60-Day-IL. Moreno (finger) was transferred to the 60-day injured list Friday.
• Ryan Thompson (Shoulder) – Status: 15-Day-IL. Thompson (shoulder) has begun a throwing program, Alex Weiner of Arizona Sports reports.
• Shelby Miller (Forearm) – Status: 15-Day-IL. Miller (forearm) began a throwing program Thursday, Alex Weiner of ArizonaSports.com reports.

Key Player Stats

Houston Astros

• Jeremy Pena: 0.322 AVG, 11 HR, 40 RBI
• Jose Altuve: 0.279 AVG, 17 HR, 53 RBI
• Isaac Paredes: 0.259 AVG, 19 HR, 50 RBI

Arizona Diamondbacks

• Eugenio Suarez: 0.254 AVG, 33 HR, 81 RBI
• Josh Naylor: 0.291 AVG, 11 HR, 58 RBI
• Geraldo Perdomo: 0.272 AVG, 10 HR, 71 RBI

Team Analysis

Houston Astros

The Houston Astros have demonstrated impressive skill at maintaining a tough lineup and an offensive rhythm that keeps opponents guessing. Their key players: Jeremy Pena, Jose Altuve, and Isaac Paredes have proven instrumental in navigating the game dynamics and delivering essential plays. Despite them losing their last game, they won their previous two, reflecting some inconsistency on the field, which they are surely keen to correct.

Looking at their recent games, the Astros are definitely looking to bounce back and find their groove. They’ll need to harness the prowess of players like Paredes and Altuve to make their scoring more efficient and increase their chances of winning. Their performance on the road has been mostly stable, but this upcoming game necessitates a strategic payback to restore their confidence.

• Batting Average: 0.258
• Total Runs Scored: 425
• Home Runs: 110
• OPS: 0.73
• ERA: 3.64
• WHIP: 1.17

Away Record: 24-23 • Home Record: 33-19
Last 5 Games: 2-3 (4.8 RPG)
Last 10 Games: 3-7 (4.5 RPG)

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Arizona Diamondbacks

The Arizona Diamondbacks, with their recent 4-1 streak in the last five games, are moving with an invigorated sense of momentum and confidence. Their offensive line headlined by Eugenio Suarez, Josh Naylor, and Geraldo Perdomo has shown an exceptional level of scoring consistency. Their recent consistency and upward trend are indicators of their readiness to face the Astros.

The Diamondbacks, coming off some compelling wins, have shown that they can handle pressure and maintain their offensive momentum. Their recent play suggests a strong probability of delivering a focused and skillful game against the Astros, particularly if Suarez and Naylor keep up their impressive performance.

• Batting Average: 0.253
• Total Runs Scored: 510
• Home Runs: 143
• OPS: 0.776
• ERA: 4.6
• WHIP: 1.33

Away Record: 24-25 • Home Record: 26-25
Last 5 Games: 4-1 (6.4 RPG)
Last 10 Games: 6-4 (5.4 RPG)

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Head-to-Head History

No recent matchups between these teams in 2025.

Over/Under Trends

Houston Astros‘s recent games have seen an average of 5.7 total runs scored per game over their last 7 matchups, with 0 games going over the total line.

Arizona Diamondbacks‘s recent games have averaged 11.9 total runs per game over their last 7 matchups, with 4 games going over the total of 9.0.

Moneyline Betting Prediction

With their offensive prowess and current upward momentum, the Arizona Diamondbacks are the wise choice. They’ve shown a significant improvement over the past few games and have a team well-equipped to maintain that trend. With key players in great form, betting on the Diamondbacks is a smart value play.

Our lean lands on the Arizona Diamondbacks at -154 to cover their edge.

Over/Under Prediction

In their last five games, the Arizona Diamondbacks have posted 6.4 runs per game, while the Houston Astros have averaged 4.8. This recent output is key to judging the total.

Recent totals have averaged around 11.2 runs per game, well above the posted total of 9.0 — a key number in MLB betting markets. Given the offensive output, our pick is Over 9.0.

Bookmakers

Odds courtesy of: BetOnline.ag, LowVig.ag, Caesars, DraftKings, MyBookie.ag, FanDuel, Bovada, BetUS, BetMGM, BetRivers, Fanatics.

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